TCR Antibodies

TCR (T-cell Receptor) antibodies are specific immunoglobulins designed to recognize and bind to the T-cell receptor (TCR), a complex of proteins found on the surface of T cells that plays a crucial role in the immune response. The TCR is responsible for recognizing antigens presented by the major histocompatibility complex (MHC) on antigen-presenting cells (APCs). TCR antibodies are essential tools in immunology for studying T-cell activation, differentiation, and function in health and disease.

Applications of TCR Antibodies
  •  T-cell Activation Assays:TCR antibodies, particularly anti-CD3, are frequently used in T-cell activation assays. By crosslinking the TCR, these antibodies mimic antigen recognition and induce T-cell activation, leading to cytokine production, proliferation, and effector function. This is particularly important for studying T-cell responses in immunotherapy, autoimmunity, and infectious diseases.
  • Immunoprecipitation (IP):TCR antibodies can be used in immunoprecipitation experiments to pull down the TCR complex and associated signaling molecules. This allows for the study of TCR interactions with intracellular signaling components such as ZAP-70 and LAT, which are critical for downstream signaling.
  •  Western Blotting:TCR antibodies are used in Western blotting to detect specific TCR chains or associated proteins like CD3. This technique helps in analyzing the expression levels of TCR proteins in different T-cell populations or following specific treatments that affect T-cell receptor signaling.
Key Considerations for Using TCR Antibodies
  • Specificity for TCR Subtypes: When selecting a TCR antibody, it is important to ensure specificity for the desired TCR subtype (e.g., α/β or γ/δ). Some antibodies are pan-TCR, recognizing all TCRs, while others are specific to particular subtypes or chains.
  • Species Reactivity: TCR antibodies may have varying reactivity with human, mouse, rat, or other species. Researchers should verify that the antibody selected is validated for use in the species under study.
  • Activation vs. Blocking: Some TCR antibodies are used to stimulate T cells by mimicking antigen engagement (e.g., anti-CD3 for activation), while others may block TCR function or interfere with antigen recognition. The choice of antibody should be based on the desired experimental outcome.
  • Crosslinking and Signal Amplification: For certain applications, such as T-cell activation assays, secondary antibodies may be required to crosslink primary TCR antibodies and enhance the signal. This is commonly done with anti-CD3 antibodies to robustly activate T cells in vitro.

TCR antibodies are essential tools for studying the structure, function, and signaling of the T-cell receptor complex. By targeting specific components of the TCR, these antibodies enable researchers to investigate T-cell activation, differentiation, and responses to various immunological challenges.

186.50 186.5 USD
AffiAB®​ Anti-Rt TCR gamma/delta Purified [V65]
CAT# AFG-XBO-2292
Size: 25 tests
155.00 155.0 USD
AffiAB®​ Anti-Rt TCR gamma/delta PE [V65]
CAT# AFG-XBO-2291
Size: 25 tests
176.00 176.0 USD
186.50 186.5 USD
AffiAB®​ Anti-Rt TCR alpha/beta Purified [R73]
CAT# AFG-XBO-2289
Size: 25 tests
155.00 155.0 USD
AffiAB®​ Anti-Rt TCR alpha/beta PE [R73]
CAT# AFG-XBO-2288
Size: 25 tests
239.00 239.0 USD
AffiAB®​ Anti-Rt TCR alpha/beta FITC [R73]
CAT# AFG-XBO-2287
Size: 25 tests
218.00 218.0 USD
134.00 134.0 USD
AffiAB®​ Anti-Ms TCR beta Purified [H57-597]
CAT# AFG-XBO-2204
Size: 100 tests
134.00 134.0 USD
AffiAB®​ Anti-Hu TCR Vgamma9 Purified [B3]
CAT# AFG-XBO-2008
Size: 100 tests
197.00 197.0 USD
AffiAB®​ Anti-Hu TCR Vgamma9 PE [B3]
CAT# AFG-XBO-2007
Size: 25 tests
281.00 281.0 USD
AffiAB®​ Anti-Hu TCR Vgamma4 Purified [4A11.904]
CAT# AFG-XBO-2006
Size: 25 tests
197.00 197.0 USD
AffiAB®​ Anti-Hu TCR Vgamma4 PE [4A11.904]
CAT# AFG-XBO-2005
Size: 25 tests
281.00 281.0 USD
AffiAB®​ Anti-Hu TCR Vdelta2 Purified [B6]
CAT# AFG-XBO-2004
Size: 25 tests
197.00 197.0 USD
AffiAB®​ Anti-Hu TCR Vdelta2 PE [B6]
CAT# AFG-XBO-2003
Size: 0.1 mg
281.00 281.0 USD
218.00 218.0 USD
218.00 218.0 USD
218.00 218.0 USD
197.00 197.0 USD
AffiAB®​ Anti-Hu TCR Valpha24-Jalpha18 PE [6B11]
CAT# AFG-XBO-1998
Size: 25 tests
281.00 281.0 USD
186.50 186.5 USD
AffiAB®​ Anti-Hu TCR gamma/delta Purified [B1]
CAT# AFG-XBO-1996
Size: 25 tests
186.50 186.5 USD
AffiAB®​ Anti-Hu TCR gamma/delta Purified [11F2]
CAT# AFG-XBO-1995
Size: 100 tests
197.00 197.0 USD
312.50 312.5 USD
AffiAB®​ Anti-Hu TCR gamma/delta PE-Cy7 [B1]
CAT# AFG-XBO-1993
Size: 25 tests
181.25 181.25 USD
AffiAB®​ Anti-Hu TCR gamma/delta PE-Cy7 [11F2]
CAT# AFG-XBO-1992
Size: 100 tests
312.50 312.5 USD
AffiAB®​ Anti-Hu TCR gamma/delta PE [B1]
CAT# AFG-XBO-1991
Size: 25 tests
165.50 165.5 USD
AffiAB®​ Anti-Hu TCR gamma/delta PE [11F2]
CAT# AFG-XBO-1990
Size: 25 tests
281.00 281.0 USD
AffiAB®​ Anti-Hu TCR gamma/delta FITC [B1]
CAT# AFG-XBO-1989
Size: 25 tests
144.50 144.5 USD
AffiAB®​ Anti-Hu TCR gamma/delta FITC [11F2]
CAT# AFG-XBO-1988
Size: 25 tests
239.00 239.0 USD
AffiAB®​ Anti-Hu TCR gamma/delta APC [11F2]
CAT# AFG-XBO-1987
Size: 25 tests
281.00 281.0 USD
AffiAB®​ Anti-Hu TCR Cbeta1 Purified [JOVI.1]
CAT# AFG-XBO-1986
Size: 25 tests
197.00 197.0 USD
AffiAB®​ Anti-Hu TCR Cbeta1 PE [JOVI.1]
CAT# AFG-XBO-1985
Size: 25 tests
281.00 281.0 USD
AffiAB®​ Anti-Hu TCR Cbeta1 FITC [JOVI.1]
CAT# AFG-XBO-1984
Size: 100 tests
239.00 239.0 USD
AffiAB®​ Anti-Hu TCR Cbeta1 APC [JOVI.1]
CAT# AFG-XBO-1983
Size: 100 tests
281.00 281.0 USD
AffiAB®​ Anti-Hu TCR alpha/beta Purified [IP26]
CAT# AFG-XBO-1982
Size: 100 tests
186.50 186.5 USD
AffiAB®​ Anti-Hu TCR alpha/beta PerCP [IP26]
CAT# AFG-XBO-1981
Size: 100 tests
165.50 165.5 USD
AffiAB®​ Anti-Hu TCR alpha/beta PE-Cy5 [IP26]
CAT# AFG-XBO-1980
Size: 100 tests
281.00 281.0 USD
AffiAB®​ Anti-Hu TCR alpha/beta PE [IP26]
CAT# AFG-XBO-1979
Size: 100 tests
165.50 165.5 USD
AffiAB®​ Anti-Hu TCR alpha/beta FITC [IP26]
CAT# AFG-XBO-1978
Size: 0.1 mg
144.50 144.5 USD
AffiAB®​ Anti-Hu TCR alpha/beta Biotin [IP26]
CAT# AFG-XBO-1977
Size: 100 tests
239.00 239.0 USD
AffiAB®​ Anti-Hu TCR alpha/beta APC [IP26]
CAT# AFG-XBO-1976
Size: 100 tests
165.50 165.5 USD
576.25 576.25 USD
576.25 576.25 USD
AffiAB® Rabbit anti-PTCRA Antibody
CAT# AFG-DDA-0979
Size: 100 μL
256.50 256.5 USD
AffiAB® Rabbit anti-PTCRA Antibody
CAT# AFG-YBP-6702
Size: 100 µL
457.00 457.0 USD
AffiAB® Anti-Hu TCR alpha/beta PE-Cy5 [IP26]
CAT# AFG-EXB-2263
Size: 100 Tests
281.00 281.0 USD
AffiAB® Anti-Hu TCR gamma/delta PE-Cy7 [11F2]
CAT# AFG-EXB-2237
Size: 100 Tests
312.50 312.5 USD
AffiAB® Anti-Hu TCR gamma/delta PE-Cy7 [B1]
CAT# AFG-EXB-2155
Size: 100 Tests
312.50 312.5 USD
312.50 312.5 USD
AffiAB® Anti-Hu TCR alpha/beta PerCP [IP26]
CAT# AFG-EXB-2053
Size: 100 Tests
281.00 281.0 USD
AffiAB® Anti-Hu TCR Valpha24-Jalpha18 PE [6B11]
CAT# AFG-EXB-1738
Size: 100 Tests
281.00 281.0 USD
AffiAB® Anti-Hu TCR gamma/delta PE [11F2]
CAT# AFG-EXB-1732
Size: 100 Tests
281.00 281.0 USD
AffiAB® Anti-Hu TCR Vdelta2 PE [B6]
CAT# AFG-EXB-1730
Size: 100 Tests
281.00 281.0 USD
AffiAB® Anti-Hu TCR Vgamma4 PE [4A11.904]
CAT# AFG-EXB-1729
Size: 100 Tests
281.00 281.0 USD
AffiAB® Anti-Hu TCR Vgamma9 PE [B3]
CAT# AFG-EXB-1728
Size: 100 Tests
281.00 281.0 USD
AffiAB® Anti-Hu TCR Cbeta1 PE [JOVI.1]
CAT# AFG-EXB-1702
Size: 100 Tests
281.00 281.0 USD
AffiAB® Anti-Rt TCR gamma/delta PE [V65]
CAT# AFG-EXB-1568
Size: 100 Tests
176.00 176.0 USD
AffiAB® Anti-Rt TCR alpha/beta PE [R73]
CAT# AFG-EXB-1567
Size: 100 Tests
239.00 239.0 USD
AffiAB® Anti-Hu TCR alpha/beta PE [IP26]
CAT# AFG-EXB-1545
Size: 0.1 mg
281.00 281.0 USD
AffiAB® Anti-Hu TCR gamma/delta PE [B1]
CAT# AFG-EXB-1372
Size: 100 Tests
281.00 281.0 USD
AffiAB® Anti-Hu TCR gamma/delta FITC [11F2]
CAT# AFG-EXB-1351
Size: 0.1 mg
239.00 239.0 USD
AffiAB® Anti-Hu TCR Cbeta1 FITC [JOVI.1]
CAT# AFG-EXB-1345
Size: 100 Tests
239.00 239.0 USD
AffiAB® Anti-Rt TCR alpha/beta FITC [R73]
CAT# AFG-EXB-1290
Size: 0.1 mg
218.00 218.0 USD
AffiAB® Anti-Hu TCR alpha/beta FITC [IP26]
CAT# AFG-EXB-1269
Size: 100 Tests
239.00 239.0 USD
AffiAB® Anti-Hu TCR gamma/delta FITC [B1]
CAT# AFG-EXB-1132
Size: 0.1 mg
239.00 239.0 USD
AffiAB® Anti-Hu TCR alpha/beta Biotin [IP26]
CAT# AFG-EXB-1100
Size: 0.1 mg
239.00 239.0 USD
AffiAB® Anti-Hu TCR gamma/delta APC [11F2]
CAT# AFG-EXB-1016
Size: 100 Tests
281.00 281.0 USD
AffiAB® Anti-Hu TCR Cbeta1 APC [JOVI.1]
CAT# AFG-EXB-1008
Size: 100 Tests
281.00 281.0 USD
AffiAB® Anti-Hu TCR alpha/beta APC [IP26]
CAT# AFG-EXB-0921
Size: 100 Tests
281.00 281.0 USD
186.50 186.5 USD
186.50 186.5 USD
134.00 134.0 USD
218.00 218.0 USD
186.50 186.5 USD
197.00 197.0 USD
AffiAB® Anti-Hu TCR gamma/delta Purified [11F2]
CAT# AFG-EXB-0680
Size: 0.1 mg
197.00 197.0 USD
AffiAB® Anti-Hu TCR Vdelta2 Purified [B6]
CAT# AFG-EXB-0674
Size: 0.1 mg
197.00 197.0 USD
AffiAB® Anti-Hu TCR Vgamma4 Purified [4A11.904]
CAT# AFG-EXB-0673
Size: 0.1 mg
197.00 197.0 USD
AffiAB® Anti-Hu TCR Vgamma9 Purified [B3]
CAT# AFG-EXB-0672
Size: 0.1 mg
197.00 197.0 USD
AffiAB® Anti-Hu TCR Cbeta1 Purified [JOVI.1]
CAT# AFG-EXB-0626
Size: 0.1 mg
197.00 197.0 USD
AffiAB® Anti-Rt TCR gamma/delta Purified [V65]
CAT# AFG-EXB-0465
Size: 0.1 mg
155.00 155.0 USD
AffiAB® Anti-Rt TCR alpha/beta Purified [R73]
CAT# AFG-EXB-0464
Size: 0.1 mg
155.00 155.0 USD
AffiAB® Anti-Hu TCR alpha/beta Purified [IP26]
CAT# AFG-EXB-0431
Size: 0.1 mg
186.50 186.5 USD
AffiAB® Anti-Ms TCR beta Purified [H57-597]
CAT# AFG-EXB-0403
Size: 0.1 mg
134.00 134.0 USD
218.00 218.0 USD
AffiAB® Anti-Hu TCR gamma/delta Purified [B1]
CAT# AFG-EXB-0073
Size: 0.1 mg
186.50 186.5 USD
218.00 218.0 USD
AffiAB® PerCP/Cyanine5.5 Anti-Mouse TCRβ Antibody
CAT# AFG-DDF-2346
Size: 100 μg
600.00 600.0 USD
AffiAB® PerCP/Cyanine5.5 Anti-Mouse TCRβ Antibody
CAT# AFG-DDF-2345
Size: 100 Tests
382.50 382.5 USD
AffiAB® PE/Cyanine7 Anti-Mouse TCRβ Antibody
CAT# AFG-DDF-2123
Size: 100 μg
555.00 555.0 USD
AffiAB® PE/Cyanine7 Anti-Mouse TCRβ Antibody
CAT# AFG-DDF-2122
Size: 100 Tests
382.50 382.5 USD
AffiAB® PE/Cyanine7 Anti-Human TCR γ/δ Antibody
CAT# AFG-DDF-2034
Size: 100 Tests
697.50 697.5 USD
AffiAB® PE/Cyanine5.5 Anti-Mouse TCRβ Antibody
CAT# AFG-DDF-1948
Size: 100 μg
600.00 600.0 USD
AffiAB® PE/Cyanine5.5 Anti-Mouse TCRβ Antibody
CAT# AFG-DDF-1947
Size: 100 Tests
382.50 382.5 USD
AffiAB® PE/Cyanine5.5 Anti-Human TCR γ/δ Antibody
CAT# AFG-DDF-1860
Size: 100 Tests
697.50 697.5 USD
AffiAB® PE/Cyanine5 Anti-Mouse TCRβ Antibody
CAT# AFG-DDF-1792
Size: 100 μg
555.00 555.0 USD
AffiAB® PE/Cyanine5 Anti-Mouse TCRβ Antibody
CAT# AFG-DDF-1791
Size: 100 Tests
382.50 382.5 USD