![AffiAB® Anti-Hu TCR Valpha24-Jalpha18 Purified [6B11]](/web/image/product.product/79664/image_1024/%5BAFG-EXB-0694%5D%20AffiAB%C2%AE%20Anti-Hu%20TCR%20Valpha24-Jalpha18%20Purified%20%5B6B11%5D?unique=06fe5f0)
Overview
TCR alpha V24-J18 chain is a marker of invariant NK T cells (iNKT) . This chain pairs mostly with TCR beta V11 chain, and together they interact with glycolipide-loaded CD1d. This interaction results in iNKT activation and cytokine production (IFN gamma, IL-4, IL-13), which takes important part in immune regulation and host response to pathogens and cancer (support of both Th1 and Th2 way), although iNKT cells represent less than 1% of total peripheral T cells.
Specificity:
The mouse monoclonal antibody 6B11 recognizes an extracellular epitope within V alpha 24 J alpha 18 TCR, which is expressed by invariant NK T cells (iNKT) .
Antigen
TCR Valpha24-Jalpha18
Clone
6B11
Species Reactivity
Human, Non-human primates
Negative Species
N/A
Isotype
Mouse IgG1 kappa
Immunogen
N/A
Application
ICC, FC (QC tested), IHC (F)
Regulatory status
RUO
Concentration
1 mg/ml
Format
Purified
Storage / Stability
Store at 2-8°C. Do not freeze.
Storage Buffer
Phosphate buffered saline (PBS), pH 7.4, 15 mM sodium azide