![AffiAB® Anti-Hu TCR Valpha24-Jalpha18 PE [6B11]](/web/image/product.product/83237/image_1024/%5BAFG-EXB-1738%5D%20AffiAB%C2%AE%20Anti-Hu%20TCR%20Valpha24-Jalpha18%20PE%20%5B6B11%5D?unique=0daa593)
Overview
TCR alpha V24-J18 chain is a marker of invariant NK T cells (iNKT) . This chain pairs mostly with TCR beta V11 chain, and together they interact with glycolipide-loaded CD1d. This interaction results in iNKT activation and cytokine production (IFN gamma, IL-4, IL-13), which takes important part in immune regulation and host response to pathogens and cancer (support of both Th1 and Th2 way), although iNKT cells represent less than 1% of total peripheral T cells.
Specificity:
The mouse monoclonal antibody 6B11 recognizes an extracellular epitope within V alpha 24 J alpha 18 TCR, which is expressed by invariant NK T cells (iNKT) .
Antigen
TCR Valpha24-Jalpha18
Clone
6B11
Species Reactivity
Human, Non-human primates
Negative Species
N/A
Isotype
Mouse IgG1 kappa
Immunogen
N/A
Application
FC (QC tested)
Regulatory status
RUO
Concentration
N/A
Format
PE
Storage / Stability
Store at 2-8°C. Protect from prolonged exposure to light. Do not freeze.
Storage Buffer
Stabilizing phosphate buffered saline (PBS), pH 7.4, 15 mM sodium azide