![AffiAB® Anti-Ms TCR beta Purified Low Endotoxin [H57-597]](/web/image/product.product/79718/image_1024/%5BAFG-EXB-0748%5D%20AffiAB%C2%AE%20Anti-Ms%20TCR%20beta%20Purified%20Low%20Endotoxin%20%5BH57-597%5D?unique=06fe5f0)
Overview
The antigen-specific T cell receptor (TCR) is composed of either alpha and beta subunit, or gamma and delta subunit. Majority of T cells present in the blood, lymph and secondary lymphoid organs express TCR alpha/beta heterodimers, whereas the T cells expressing TCR gamma/delta heterodimers are localized mainly in epithelial tissues and at the sites of infection. The subunits of TCR heterodimers are covalently bonded and in the endoplasmic reticulum they associate with CD3 subunits to form functional TCR-CD3 complex. Lack of expression of any of the chains is sufficient to stop cell surface expression.
Specificity:
The Armenian hamster monoclonal antibody H57-597 reacts specifically with an extracellular epitope on beta subunit of TCR alpha/beta. This antibody does not crossreact with TCR gamma/delta type and has been used as TCR alpha/beta phenotypic marker.
Antigen
TCR beta
Clone
H57-597
Species Reactivity
Mouse
Negative Species
N/A
Isotype
Armenian Hamster IgG2b kappa
Immunogen
Affinity purified TCR from DO-11.10 T cell hybridoma
Application
FC (QC tested), IP, IHC (P), IHC (F), ICC, FUNC
Regulatory status
RUO
Concentration
1 mg/ml
Format
Purified Low Endotoxin
Storage / Stability
Store at 2-8°C. Do not freeze.
Storage Buffer
Phosphate buffered saline (PBS), pH 7.4