IRAK Antibodies

Interleukin-1 receptor-associated kinase (IRAK) is a key signaling kinase involved in the Toll-like receptor (TLR) and interleukin-1 receptor (IL-1R) pathways, which are critical for innate immune responses. IRAK family proteins (IRAK1, IRAK2, IRAK3/IRAK-M, and IRAK4) play distinct roles in mediating the activation of nuclear factor kappa B (NF-κB), mitogen-activated protein kinases (MAPKs), and the production of pro-inflammatory cytokines. Dysregulation of IRAK activity has been implicated in inflammatory diseases, autoimmune disorders, and cancer, making IRAK antibodies essential for studying these signaling pathways in various biological contexts.

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IRAK antibodies are immunological reagents that target individual IRAK proteins, enabling their detection, quantification, and functional analysis in different experimental systems. Monoclonal IRAK antibodies, which bind to a single epitope, provide high specificity and reproducibility, making them ideal for precise applications. Polyclonal antibodies, which recognize multiple epitopes, offer increased sensitivity, particularly for detecting low-abundance IRAK proteins.

Applications of IRAK Antibody
  • Innate Immune Response and Inflammation Research: IRAK proteins are critical mediators of innate immune responses triggered by TLR and IL-1R signaling. IRAK antibodies are used extensively in research focused on the immune system to study how IRAK proteins regulate inflammation. For example, IRAK1 and IRAK4 antibodies are used to monitor activation and phosphorylation status in response to pathogen-associated molecular patterns (PAMPs), such as lipopolysaccharide (LPS). 
  • Autoimmune and Inflammatory Disease Studies: Dysregulated IRAK signaling has been linked to the development of autoimmune and inflammatory diseases such as rheumatoid arthritis, systemic lupus erythematosus (SLE), and inflammatory bowel disease (IBD). IRAK antibodies are used to study the aberrant activation of IRAK proteins in these diseases. 
  • Cancer Research: IRAK signaling has been implicated in tumorigenesis, particularly in cancers associated with chronic inflammation, such as colorectal cancer, liver cancer, and hematologic malignancies. IRAK antibodies are used in cancer research to study how IRAK-driven inflammation contributes to cancer progression and metastasis. 

IRAK antibodies are invaluable tools in studying the role of IRAK proteins in immune signaling, inflammation, autoimmune diseases, and cancer. These antibodies enable the precise detection, quantification, and functional analysis of IRAK family members in a variety of biological contexts. 


AffiAB® Rabbit Anti-IRAK1 Antibody
CAT# AFG-DDA-8817
Size: 100 μL
284.05 284.05 USD
AffiAB® Rabbit anti-IRAK4 Antibody
CAT# AFG-DDA-3049
Size: 100 μL
284.05 284.05 USD
AffiAB® Rabbit anti-IRAK3 Antibody
CAT# AFG-DDA-2606
Size: 100 μL
284.05 284.05 USD
AffiAB® Rabbit anti-IRAK1 (pT209) Antibody
CAT# AFG-DDA-1060
Size: 100 μL
274.55 274.55 USD
AffiAB® Rabbit anti-IRAK2 Antibody
CAT# AFG-DDA-0044
Size: 100 μL
256.50 256.5 USD
AffiAB® IRAK4 Polyclonal Antibody
CAT# AFG-PAB-07594
Size: 100 µL
Conjugation: Unconjugated
533.50 533.5 USD
AffiAB® IRAK3 Polyclonal Antibody
CAT# AFG-PAB-07593
Size: 100 µg
Conjugation: Unconjugated
335.50 335.5 USD
AffiAB® IRAK2 Polyclonal Antibody
CAT# AFG-PAB-07592
Size: 100 µg
Conjugation: Unconjugated
335.50 335.5 USD
AffiAB® IRAK1BP1 Polyclonal Antibody
CAT# AFG-PAB-07591
Size: 100 µL
Conjugation: Unconjugated
533.50 533.5 USD
AffiAB® Phospho-IRAK1 - Ser376 Polyclonal Antibody
CAT# AFG-PAB-07590
Size: 100ul
Conjugation: Unconjugated
625.00 625.0 USD
AffiAB® Phospho-IRAK1 - T387 Polyclonal Antibody
CAT# AFG-PAB-07589
Size: 100 µg
Conjugation: Unconjugated
335.50 335.5 USD
AffiAB® Phospho-IRAK1 - S376 Polyclonal Antibody
CAT# AFG-PAB-07588
Size: 100 µg
Conjugation: Unconjugated
335.50 335.5 USD
AffiAB® Phospho-IRAK1 - T100 Polyclonal Antibody
CAT# AFG-PAB-07587
Size: 100 µg
Conjugation: Unconjugated
335.50 335.5 USD
AffiAB® Phospho-IRAK1 - T209 Polyclonal Antibody
CAT# AFG-PAB-07586
Size: 100 µg
Conjugation: Unconjugated
335.50 335.5 USD
AffiAB® IRAK1 Polyclonal Antibody
CAT# AFG-PAB-07585
Size: 100 µg
Conjugation: Unconjugated
335.50 335.5 USD
AffiAB® Rabbit anti-IRAK4 Antibody
CAT# AFG-YBP-4614
Size: 100 µL
457.00 457.0 USD
AffiAB® Rabbit anti-IRAK3 Antibody
CAT# AFG-YBP-4613
Size: 100 µL
457.00 457.0 USD
AffiAB® Rabbit anti-IRAK2 Antibody
CAT# AFG-YBP-4612
Size: 100 µL
457.00 457.0 USD
AffiAB® Rabbit anti-IRAK1 (pT209) Antibody
CAT# AFG-YBP-4611
Size: 100 µL
457.00 457.0 USD
AffiAB® Anti-IRAKM Antibody [SN64-07]
CAT# AFG-HB-2151
Size: 100 μL
496.50 496.5 USD
AffiAB® Anti-IRAK2 Antibody [JG36-23]
CAT# AFG-HB-2150
Size: 100 μL
496.50 496.5 USD
AffiAB® Anti-IRAK-1 Antibody [JE60-03]
CAT# AFG-HB-2149
Size: 100 μL
496.50 496.5 USD
AffiAB® Anti-IRAK-1 Antibody
CAT# AFG-HB-2148
Size: 100 μL
433.50 433.5 USD
AffiAB® Anti-IRAK-4 Antibody (Phospho-Thr345)
CAT# AFG-IVA-01624
Size: 100 µg
Terminal: N/A
692.15 692.15 USD
AffiAB® IRAK-M Rabbit Polyclonal Antibody
CAT# AFG-EKA-04121
Size: 100 µL
246.00 246.0 USD
AffiAB® IRAK-2 Rabbit Polyclonal Antibody
CAT# AFG-EKA-02147
Size: 100 µL
246.00 246.0 USD
AffiAB® IRAK-1 Rabbit Polyclonal Antibody
CAT# AFG-EKA-02146
Size: 100 µL
246.00 246.0 USD