SIGLEC Antibodies

Function and Importance of Siglec Antibodies: Siglec antibodies are used to detect and quantify Siglec proteins in various research applications. They are particularly valuable for studying how Siglecs regulate immune responses, modulate inflammation, and maintain immune homeostasis. Siglecs have an immunomodulatory role, often delivering inhibitory signals through immunoreceptor tyrosine-based inhibitory motifs (ITIMs) present in their cytoplasmic domains. 

Applications of Siglec antibodies include:

  • Western Blot (WB): For detecting Siglec proteins in cell lysates or tissue samples, allowing for quantitative analysis of Siglec expression.
  • Flow Cytometry (FACS): Used to analyze the surface expression of Siglecs on immune cells, providing insights into their role in immune regulation.
  • Immunohistochemistry (IHC): For localizing Siglecs in tissues, particularly in lymphoid organs, tumors, or inflamed tissues.
  • Immunoprecipitation (IP): To study protein-protein interactions involving Siglecs, often used to elucidate signaling pathways associated with immune inhibition.

Siglec Antibody Applications in Research:

  • Immunotherapy: Siglec antibodies, particularly those targeting inhibitory Siglecs like Siglec-7 and Siglec-9, are being explored for their potential in cancer immunotherapy. By blocking these inhibitory receptors, Siglec-targeting antibodies can reinvigorate the immune response against tumors.
  • Autoimmunity Research: Antibodies against Siglec-2 (CD22) are used to investigate B cell regulation and its impact on autoimmune diseases. Therapies targeting CD22 are being developed for B cell depletion in autoimmune conditions.
  • Neuroscience Research: Siglec-4 antibodies are used in studies of neurodegenerative diseases and demyelination, as Siglec-4 plays a protective role in maintaining the myelin sheath around neurons.
  • Viral and Bacterial Pathogenesis: Siglec antibodies help researchers understand how pathogens interact with Siglec receptors to modulate immune evasion and host-pathogen interactions. Siglec-1 and Siglec-3 antibodies are commonly used in studies on HIV, Neisseria, and other sialylated pathogens.

Siglec antibodies are indispensable tools for studying the complex roles of Siglecs in immune regulation, pathogen interactions, and disease pathogenesis. By targeting specific Siglec receptors, researchers can explore their role in immune tolerance, cancer evasion, and autoimmunity. In addition to basic research, Siglec antibodies hold promise for therapeutic applications, particularly in cancer immunotherapy and autoimmune disease management. 

AffiAB® Rabbit anti-Siglec 12 Antibody
CAT# AFG-DDA-1608
Size: 100 μL
274.55 274.55 USD
AffiAB® SIGLEC9 Polyclonal Antibody
CAT# AFG-PAB-13844
Size: 150 µL
Conjugation: Unconjugated
1,112.50 1112.5 USD
AffiAB® SIGLEC8 Polyclonal Antibody
CAT# AFG-PAB-13843
Size: 100 µg
Conjugation: Unconjugated
335.50 335.5 USD
AffiAB® SIGLEC7 Polyclonal Antibody
CAT# AFG-PAB-13842
Size: 100 µg
Conjugation: Unconjugated
335.50 335.5 USD
AffiAB® SIGLEC6 Polyclonal Antibody
CAT# AFG-PAB-13841
Size: 150 µL
Conjugation: Unconjugated
1,112.50 1112.5 USD
AffiAB® SIGLEC5 Polyclonal Antibody
CAT# AFG-PAB-13840
Size: 100 µg
Conjugation: Unconjugated
335.50 335.5 USD
AffiAB® SIGLEC15 Polyclonal Antibody
CAT# AFG-PAB-13839
Size: 100 µL
Conjugation: Unconjugated
533.50 533.5 USD
AffiAB® SIGLEC14 Polyclonal Antibody
CAT# AFG-PAB-13838
Size: 100 µL
Conjugation: Unconjugated
533.50 533.5 USD
AffiAB® SIGLEC12 Polyclonal Antibody
CAT# AFG-PAB-13837
Size: 100 µL
Conjugation: Unconjugated
533.50 533.5 USD
AffiAB® SIGLEC11 Polyclonal Antibody
CAT# AFG-PAB-13836
Size: 100 µL
Conjugation: Unconjugated
533.50 533.5 USD
AffiAB® SIGLEC10 Polyclonal Antibody
CAT# AFG-PAB-13835
Size: 100 µL
Conjugation: Unconjugated
533.50 533.5 USD
AffiAB® SIGLEC1 Polyclonal Antibody
CAT# AFG-PAB-13834
Size: 100 µg
Conjugation: Unconjugated
335.50 335.5 USD
AffiAB® Rabbit anti-Siglec 12 Antibody
CAT# AFG-YBP-7376
Size: 100 µL
457.00 457.0 USD
AffiAB® Anti-Hu SIGLEC10 PE [5G6]
CAT# AFG-EXB-1741
Size: 100 Tests
281.00 281.0 USD
AffiAB® Anti-Hu SIGLEC8 PE [7C9]
CAT# AFG-EXB-1699
Size: 100 Tests
281.00 281.0 USD
AffiAB® Anti-Hu SIGLEC10 Purified [5G6]
CAT# AFG-EXB-0699
Size: 0.1 mg
197.00 197.0 USD
AffiAB® Anti-Hu SIGLEC8 Purified [7C9]
CAT# AFG-EXB-0623
Size: 0.1 mg
197.00 197.0 USD
AffiAB® Siglec-5/14 Rabbit Polyclonal Antibody
CAT# AFG-EKA-03505
Size: 100 µL
246.00 246.0 USD