![AffiAB® Anti-Hu SIGLEC8 PE [7C9]](/web/image/product.product/83198/image_1024/%5BAFG-EXB-1699%5D%20AffiAB%C2%AE%20Anti-Hu%20SIGLEC8%20PE%20%5B7C9%5D?unique=0daa593)
Overview
SIGLEC8 is a sialic acid binding lectin similar to CD33. In its cytoplasmic comain it contains an immunoreceptor tyrosine-based inhibitory motif (ITIM), and a motive similar to a binding site for SLAM-associated protein. SIGLEC8 is expressed e.g. in lymph nodes and spleen. It is an eosinophil marker, although it can be found also on the surface of mast cells. Crosslinking of SIGLEC8 leads to apoptosis. Soluble form of SIGLEC8 can be foud in human serum, especially in case of eosinophil-associated diseases.
Specificity:
The mouse monoclonal antibody 7C9 recognizes an extracellular epitope of SIGLEC8, an eosinophil marker, expressed e.g. in lymph nodes and spleen.
Antigen
SIGLEC8
Clone
7C9
Species Reactivity
Human
Negative Species
N/A
Isotype
Mouse IgG1
Immunogen
Extracellular domain of human SIGLEC8 fused with Fc fragment of human IgG1
Application
FC (QC tested)
Regulatory status
RUO
Concentration
N/A
Format
PE
Storage / Stability
Store at 2-8°C. Protect from prolonged exposure to light. Do not freeze.
Storage Buffer
Stabilizing phosphate buffered saline (PBS), pH 7.4, 15 mM sodium azide