![AffiAB® Anti-Hu SIGLEC10 Purified [5G6]](/web/image/product.product/79669/image_1024/%5BAFG-EXB-0699%5D%20AffiAB%C2%AE%20Anti-Hu%20SIGLEC10%20Purified%20%5B5G6%5D?unique=06fe5f0)
Overview
SIGLEC10 is a CD33-related receptor of sialoglycans, expressed on eosinophils, monocytes, a subpopulation of NK cells, and at lower level on B cells. Its murine ortholog is Siglec G. SIGLEC10 seems to act as an immunomodulatory receptor, which binds to VAP-1, a glycoprotein expressed on endothelium under inflammatory conditions. Another ligand of SIGLEC10 is CD24, a marker of poorer prognosis in carcinomas.
Specificity:
The mouse monoclonal antibody 5G6 recognizes an extracellular epitope of human SIGLEC10, a sialic acid-binding lectin expressed on subsets of human leucocytes.
Antigen
SIGLEC10
Clone
5G6
Species Reactivity
Human
Negative Species
N/A
Isotype
Mouse IgG1
Immunogen
SIGLEC10 extracellular domain fused with human IgG1 Fc fragment
Application
IHC, ELISA, IP
Regulatory status
RUO
Concentration
1 mg/ml
Format
Purified
Storage / Stability
Store at 2-8°C. Do not freeze.
Storage Buffer
Phosphate buffered saline (PBS), pH 7.4, 15 mM sodium azide