PSMA Antibodies

Gene Name: PSMA (Prostate-Specific Membrane Antigen)

Function:

  • PSMA is a cell surface glycoprotein that is highly expressed in prostate epithelial cells, particularly in prostate cancer cells.
  • It plays a role in the internalization and metabolism of folate, as well as in cell adhesion, migration, and invasion processes.

Immune Regulation:

  • PSMA expression on tumor cells may influence immune responses within the tumor microenvironment.
  • Tumors expressing PSMA may exhibit altered immune cell infiltration, cytokine production, and immune checkpoint molecule expression.
  • Targeting PSMA-positive tumor cells with immunotherapeutic approaches, such as monoclonal antibodies or CAR-T cell therapies, aims to enhance anti-tumor immune responses and overcome immune evasion mechanisms.

Apoptosis:

  • While the direct role of PSMA in apoptosis regulation is not fully understood, dysregulation of PSMA expression or activity may impact apoptotic signaling pathways, contributing to cancer cell survival and tumor progression.

Research Implications:

  • Understanding the functions of PSMA is essential for elucidating its roles in cancer development and progression.
  • Research on PSMA may have implications for the development of targeted therapies and immunotherapies for PSMA-positive cancers, including prostate cancer and certain solid tumors.

Clinical Relevance:

  • PSMA is a clinically validated biomarker and therapeutic target in prostate cancer.
  • PSMA-targeted therapies, such as radioligand therapy (e.g., lutetium-177 PSMA radioligand therapy) and antibody-drug conjugates (ADCs), are being developed and evaluated in clinical trials for the treatment of PSMA-positive malignancies.
  • Additionally, PSMA-directed CAR-T cell therapies are being investigated as a novel approach for treating PSMA-positive cancers, particularly in cases of treatment-resistant or advanced disease.
624.55 624.5500000000001 USD
624.55 624.5500000000001 USD
624.55 624.5500000000001 USD
624.55 624.5500000000001 USD
624.55 624.5500000000001 USD
506.85 506.85 USD
506.85 506.85 USD
506.85 506.85 USD
AffiAB® Anti-PSMA5 Antibody
CAT# AFG-BRB-23000
Size: 80 μL
293.10 293.1 USD
542.00 542.0 USD
506.85 506.85 USD
506.85 506.85 USD
AffiAB® Anti-PSMAL Antibody (Center)
CAT# AFG-BRB-20143
Size: 80 μL
293.10 293.1 USD
AffiAB® Anti-PSMA6 Antibody (N-Term)
CAT# AFG-BRB-20022
Size: 50 μL
293.10 293.1 USD
AffiAB® Anti-PSMA5 Antibody
CAT# AFG-BRB-19725
Size: 50 μL
293.10 293.1 USD
AffiAB® Rabbit Anti-PSA6/PSMA6 Polyclonal Antibody
CAT# AFG-KMD-2962
Size: 100 μL
399.50 399.5 USD
326.35 326.35 USD
AffiAB® Anti-PSMA FOLH1 Antibody
CAT# AFG-BRB-02632
Size: 100 μL
352.00 352.0 USD
AffiAB®​ Anti-PSMA Purified [GCP-05]
CAT# AFG-XBO-2262
Size: 100 tests
190.50 190.5 USD
AffiAB®​ Anti-PSMA Purified [GCP-04]
CAT# AFG-XBO-2261
Size: 25 tests
190.50 190.5 USD
AffiAB®​ Anti-PSMA PE [GCP-05]
CAT# AFG-XBO-2260
Size: 25 tests
323.50 323.5 USD
AffiAB®​ Anti-PSMA Alexa Fluor 488 [GCP-05]
CAT# AFG-XBO-2259
Size: 25 tests
352.00 352.0 USD
AffiAB® Human PSMA7 Antibody
CAT# AFG-SYP-2036
Size: 150 μg
214.25 214.25 USD
AffiAB® Human PSMA4 Antibody
CAT# AFG-SYP-2035
Size: 150 μg
214.25 214.25 USD
AffiAB® Human PSMA2 Antibody
CAT# AFG-SYP-2034
Size: 150 μg
214.25 214.25 USD
AffiAB® Mouse anti-PSMA Antibody
CAT# AFG-DDA-9571
Size: 100 μL
284.05 284.05 USD
AffiAB® Mouse anti-PSMA Antibody
CAT# AFG-DDA-9492
Size: 100 μL
284.05 284.05 USD
AffiAB® Rabbit Anti-PSMA4 Antibody
CAT# AFG-DDA-6654
Size: 100 μL
317.30 317.3 USD
AffiAB® Rabbit Anti-PSMA2 Antibody
CAT# AFG-DDA-6653
Size: 100 μL
317.30 317.3 USD
AffiAB® Rabbit Anti-PSMA6 Antibody
CAT# AFG-DDA-6651
Size: 100 μL
317.30 317.3 USD
AffiAB® Rabbit Anti-PSMA3 Antibody
CAT# AFG-DDA-5983
Size: 100 μL
308.75 308.75 USD
AffiAB® Rabbit Anti-PSMA5 Antibody
CAT# AFG-DDA-5675
Size: 100 μL
308.75 308.75 USD
AffiAB® Rabbit Anti-PSMA1 Antibody
CAT# AFG-DDA-5628
Size: 100 μL
308.75 308.75 USD
AffiAB® Rabbit anti-PSMA7 Antibody
CAT# AFG-DDA-3645
Size: 100 μL
284.05 284.05 USD
AffiAB® PSMA8 Polyclonal Antibody
CAT# AFG-PAB-12231
Size: 150 µL
Conjugation: Unconjugated
785.00 785.0 USD
AffiAB® PSMA7 Polyclonal Antibody
CAT# AFG-PAB-12230
Size: 150 µL
Conjugation: Unconjugated
785.00 785.0 USD
AffiAB® PSMA6 Polyclonal Antibody
CAT# AFG-PAB-12229
Size: 150 µL
Conjugation: Unconjugated
785.00 785.0 USD
AffiAB® PSMA5 Polyclonal Antibody
CAT# AFG-PAB-12228
Size: 100 µg
Conjugation: Unconjugated
399.00 399.0 USD
AffiAB® PSMA4 Polyclonal Antibody
CAT# AFG-PAB-12227
Size: 150 µL
Conjugation: Unconjugated
785.00 785.0 USD
AffiAB® Phospho-PSMA3 - Ser250 Polyclonal Antibody
CAT# AFG-PAB-12226
Size: 100ul
Conjugation: Unconjugated
460.00 460.0 USD
AffiAB® PSMA3 Polyclonal Antibody
CAT# AFG-PAB-12225
Size: 150 µL
Conjugation: Unconjugated
785.00 785.0 USD
AffiAB® Phospho-PSMA3 - S250 Polyclonal Antibody
CAT# AFG-PAB-12224
Size: 100 µg
Conjugation: Unconjugated
267.00 267.0 USD
AffiAB® PSMA2 Polyclonal Antibody
CAT# AFG-PAB-12223
Size: 100 µg
Conjugation: Unconjugated
399.00 399.0 USD
AffiAB® PSMA1 Polyclonal Antibody
CAT# AFG-PAB-12222
Size: 150 µL
Conjugation: Unconjugated
785.00 785.0 USD
AffiAB® Rabbit anti-PSMA7 Antibody
CAT# AFG-YBP-6669
Size: 100 µL
457.00 457.0 USD
AffiAB® Rabbit anti-PSMA6 Antibody
CAT# AFG-YBP-6668
Size: 100 µL
457.00 457.0 USD
AffiAB® Rabbit anti-PSMA5 Antibody
CAT# AFG-YBP-6667
Size: 100 µL
457.00 457.0 USD
AffiAB® Rabbit anti-PSMA4 Antibody
CAT# AFG-YBP-6666
Size: 100 µL
457.00 457.0 USD
AffiAB® Rabbit anti-PSMA3 Antibody
CAT# AFG-YBP-6665
Size: 100 µL
457.00 457.0 USD
AffiAB® Rabbit anti-PSMA2 Antibody
CAT# AFG-YBP-6664
Size: 100 µL
457.00 457.0 USD
AffiAB® Rabbit anti-PSMA1 Antibody
CAT# AFG-YBP-6663
Size: 100 µL
457.00 457.0 USD
AffiAB® Anti-PSMA7 Antibody
CAT# AFG-HB-3283
Size: 100 μL
283.50 283.5 USD
AffiAB® Anti-PSMA5 Antibody
CAT# AFG-HB-3282
Size: 100 μL
283.50 283.5 USD
AffiAB® Anti-PSMA4 Antibody
CAT# AFG-HB-3281
Size: 100 μL
283.50 283.5 USD
AffiAB® Anti-PSMA3 Antibody [JE51-59]
CAT# AFG-HB-3280
Size: 100 μL
346.50 346.5 USD
AffiAB® Anti-PSMA2 Antibody [JE51-51]
CAT# AFG-HB-3279
Size: 100 μL
346.50 346.5 USD
AffiAB® Anti-PSMA1 Antibody [JU66-24]
CAT# AFG-HB-3278
Size: 100 μL
346.50 346.5 USD
AffiAB® Anti-PSMA Antibody [A5G5]
CAT# AFG-HB-3277
Size: 100 μL
315.00 315.0 USD