Mesothelin Antibodies

Gene Name: Mesothelin (MSLN)

Function:

• Mesothelin is a cell surface glycoprotein that is highly expressed in mesothelial cells lining the pleura, pericardium, and peritoneum.
• It plays a role in cell adhesion, cell signaling, and the regulation of cell growth and survival.

Immune Regulation:

• Mesothelin expression on tumor cells may influence immune responses within the tumor microenvironment.
• Tumors expressing mesothelin may exhibit altered immune cell infiltration, cytokine production, and immune checkpoint molecule expression.
• Targeting mesothelin-positive tumor cells with immunotherapeutic approaches, such as monoclonal antibodies or CAR-T cell therapies, aims to enhance anti-tumor immune responses and overcome immune evasion mechanisms.

Apoptosis:

• While the direct role of mesothelin in apoptosis regulation is not fully understood, dysregulation of mesothelin expression or activity may impact apoptotic signaling pathways, contributing to cancer cell survival and tumor progression.

Research Implications:

• Understanding the functions of mesothelin is essential for elucidating its roles in cancer development and progression.
• Research on mesothelin may have implications for the development of targeted therapies and immunotherapies for mesothelin-positive cancers, including mesothelioma and certain solid tumors.

Clinical Relevance:

• Mesothelin is a potential therapeutic target in mesothelioma and other mesothelin-positive cancers.
• Mesothelin-targeted therapies, such as antibody-drug conjugates (ADCs) and immunotherapies, are being developed and evaluated in clinical trials for the treatment of mesothelin-positive malignancies.
• Additionally, mesothelin-directed CAR-T cell therapies are being investigated as a novel approach for treating mesothelin-positive cancers, particularly in cases of treatment-resistant or advanced disease.