REG Antibodies

REG antibodies are designed to detect Regenerating gene (REG) family proteins, which are primarily involved in cell growth, regeneration, and tissue repair. The REG family consists of several secretory proteins, such as REG1, REG3 (also known as HIP/PAP), and REG4, which are expressed in response to injury or stress, particularly in the pancreas and gastrointestinal (GI) tract. 

Applications of REG Antibodies

• Western Blotting (WB): REG antibodies are commonly used in western blotting to detect and quantify REG proteins in cell or tissue lysates. This application helps researchers investigate REG protein levels during tissue regeneration, inflammation, or cancer progression.
• Immunohistochemistry (IHC): REG antibodies are used in IHC to localize REG proteins within tissue sections. This is particularly useful for studying REG expression in diseases such as pancreatitis, IBD, and cancer, where tissue damage and regeneration are key processes.
• Immunofluorescence (IF): In immunofluorescence assays, REG antibodies allow for the visualization of REG proteins within cells or tissues, providing insights into their cellular distribution and role in tissue regeneration and immune response.

REG Antibodies in Disease Research

• Pancreatic Diseases: REG proteins are highly expressed in pancreatic islets and play a critical role in pancreatic regeneration following injury, such as in diabetes or pancreatitis. REG1 and REG3 are overexpressed in the regenerating islets of individuals with diabetes, and their role in islet cell proliferation has made them targets of therapeutic research. REG antibodies are used to study the regulation of these proteins in pancreatic injury and regeneration.
• Cancer: Overexpression of REG proteins, particularly REG4, has been implicated in the development of GI cancers, including colorectal and gastric cancers. REG4 promotes cancer cell proliferation and survival, and its expression is often associated with poor prognosis. REG antibodies are used in cancer research to study the role of REG proteins in tumorigenesis and their potential as therapeutic targets.
• Diabetes: The role of REG proteins in beta-cell regeneration and survival makes them a focus of research in diabetes treatment. REG1 is being investigated for its potential to promote islet cell regeneration in patients with type 1 diabetes. REG antibodies are used to explore the mechanisms by which REG proteins influence beta-cell survival and regeneration.

REG antibodies are essential tools for studying the diverse roles of REG proteins in tissue regeneration, inflammation, immune response, and cancer progression. Through their use in various research applications, including western blotting, immunohistochemistry, and ELISA, these antibodies help to elucidate the molecular mechanisms by which REG proteins promote cell proliferation, tissue repair, and protection against inflammation.