![AffiAB® Anti-Ms CD41 PE [MWReg30]](/web/image/product.product/83144/image_1024/%5BAFG-EXB-1645%5D%20AffiAB%C2%AE%20Anti-Ms%20CD41%20PE%20%5BMWReg30%5D?unique=d31c23b)
Overview
CD41 (platelet glycoprotein IIb) is composed of two subunits (120 kDa a, alpha and 23 kDa b, beta) that interact with CD61 in the presence of calcium to form a functional adhesive protein receptor. Upon blood vessel damage, this receptor binds to a variety of proteins including von Willebrand factor, fibrinogen, fibronectin and vitronectin. CD41 is mainly expressed on megakaryocyte-platelet lineage, but generally belongs to the antigens that are expressed during early stages of hematopoietic differentiation.
Specificity:
The rat monoclonal antibody MWReg30 recognizes an extracellular epitope of CD41 (GPIIb), a transmembrane glycoprotein (integrin family) composed of two chains GPIIb alpha (heavy chain; 120 kDa) and GPIIb beta (light chain; 23 kDa) . CD41 is mainly expressed on platelets and megakaryocytes.
Antigen
CD41
Clone
MWReg30
Species Reactivity
Mouse
Negative Species
N/A
Isotype
Rat IgG1 kappa
Immunogen
Murine platelets
Application
FC (QC tested)
Regulatory status
RUO
Concentration
0.5 mg/ml
Format
PE
Storage / Stability
Store at 2-8°C. Protect from prolonged exposure to light. Do not freeze.
Storage Buffer
Phosphate buffered saline (PBS), pH 7.4, 15 mM sodium azide