ARL Antibodies

The ARL (ADP-Ribosylation Factor-Like) gene family includes a group of genes that encode small GTPases belonging to the ADP-ribosylation factor (ARF) family. These small GTPases play essential roles in intracellular vesicle trafficking, membrane dynamics, and signaling pathways within the cell.

Here are a few examples of ARL genes:

ARL1: Involved in regulating membrane traffic and organelle structure, particularly within the Golgi apparatus.

ARL2: Plays a role in microtubule dynamics and cellular organization.

ARL3: Associated with cilia formation and function, and mutations in this gene can lead to ciliopathies.

ARL4A and ARL4D: Involved in membrane trafficking and actin remodeling.

ARL5A: Participates in intracellular vesicle trafficking.

ARL6: Also known as BBS3 (Bardet-Biedl Syndrome 3), mutations in this gene are associated with Bardet-Biedl Syndrome, a ciliopathy.

ARL9: Plays a role in ciliogenesis and cellular processes associated with primary cilia.

The functions of ARL proteins often involve their regulation of vesicle trafficking and membrane dynamics, which are essential for various cellular processes, including protein transport, organelle maintenance, and cell signaling. Mutations or dysregulation of ARL genes can be associated with various diseases, including ciliopathies and certain cancers.

The diversity of ARL genes and their functions highlight their importance in maintaining cellular homeostasis and proper functioning. Research on ARL genes contributes to our understanding of intracellular transport mechanisms and their roles in health and disease.