![AffiAB® Anti-Hu CD255 Purified [CARL-1]](/web/image/product.product/79522/image_1024/%5BAFG-EXB-0552%5D%20AffiAB%C2%AE%20Anti-Hu%20CD255%20Purified%20%5BCARL-1%5D?unique=d31c23b)
Overview
CD255 / TWEAK (TNF-related weak inducer of apoptosis), a type II transmembrane protein expressed as membrane-bound and secreted form, can induce apoptosis in many tissues and cell lines through its receptor CD266 / TWEAK R. On the other hand, in endothelial cells this interaction can induce proliferation and promote angiogenesis including neovascularization of tumours. CD255 can act in a juxtacrine manner to initiate cellular responses, and induces secretion of pro-inflammatory cytokines. Besides CD266, CD255 may also bind to DR3.
Specificity:
The mouse monoclonal antibody CARL-1 recognizes an extracellular epitope of CD255 / TWEAK, a type II transmembrane protein of the TNF superfamily able to induce apoptosis weakly in many cell types.
Antigen
CD255
Clone
CARL-1
Species Reactivity
Human
Negative Species
N/A
Isotype
Mouse IgG3 kappa
Immunogen
human CD255-transfected 2PK-3 cells
Application
FC (QC tested), IHC
Regulatory status
RUO
Concentration
1 mg/ml
Format
Purified
Storage / Stability
Store at 2-8°C. Do not freeze.
Storage Buffer
Tris buffered saline (TBS), pH 8.0, 15 mM sodium azide