FGF Antibodies

FGF (Fibroblast Growth Factor) antibodies are developed to target members of the FGF family, a group of growth factors involved in a broad range of biological functions, including cell growth, differentiation, angiogenesis, and tissue repair. The FGF family consists of 22 different proteins, each playing specific roles in cellular and developmental processes. FGFs are crucial regulators of embryonic development, wound healing, and pathological processes such as cancer and fibrosis.

Content

FGF antibodies are highly specific to individual FGF proteins, enabling the detection, quantification, and functional analysis of these growth factors in various experimental settings. These antibodies are used extensively in Western blotting, immunohistochemistry (IHC), immunoprecipitation (IP), and ELISA to study FGF signaling pathways and their involvement in cell proliferation, differentiation, and migration.

Applications

• Cancer Research: FGFs and their receptors (FGFRs) are often dysregulated in cancers, contributing to tumor growth, angiogenesis, and metastasis. FGF antibodies are used to investigate the expression of FGFs in tumor tissues, their involvement in cancer progression, and their potential as therapeutic targets in anti-angiogenic and anti-proliferative treatments.
• Developmental Biology: FGF signaling plays a key role in embryonic development, including limb formation, neural development, and organogenesis. FGF antibodies are essential tools for studying the spatial and temporal expression of FGFs during development and for understanding how disruptions in FGF signaling contribute to developmental disorders.
• Angiogenesis Studies: FGFs are critical regulators of blood vessel formation (angiogenesis). FGF antibodies are used to explore how these growth factors promote endothelial cell proliferation and vascular development, particularly in the context of wound healing, tissue regeneration, and tumor angiogenesis.
• Regenerative Medicine and Tissue Repair: FGFs are involved in tissue regeneration and wound healing by promoting cell migration and proliferation. FGF antibodies are utilized to study their roles in tissue repair mechanisms, such as skin healing, bone regeneration, and liver regeneration, with applications in regenerative medicine and stem cell research.

By employing FGF antibodies, researchers can analyze the intricate roles that FGFs play in a variety of biological processes, from tissue development and regeneration to the progression of diseases like cancer and fibrosis. These antibodies provide valuable insights into therapeutic interventions that target FGF signaling pathways.