CLIC Antibodies

CLIC (Chloride Intracellular Channel) antibodies target the CLIC family of proteins, which are involved in various cellular processes, including ion transport, apoptosis, and membrane trafficking. The CLIC family consists of several members, such as CLIC1, CLIC4, and CLIC5, which can switch between soluble and membrane-bound forms, functioning as chloride channels in both the cytoplasm and on membranes.

Content of CLIC Antibodies

CLIC antibodies are monoclonal or polyclonal antibodies that specifically detect different CLIC proteins. They are used in research to study the expression, localization, and function of CLIC proteins in various tissues.

• CLIC1: Associated with ion transport and oxidative stress response. It plays a role in cancer cell migration and is implicated in tumor progression.
• CLIC4: Involved in apoptosis, cytoskeleton remodeling, and oxidative stress regulation. Its dysregulation has been linked to cancer and fibrosis.
• CLIC5: Primarily found in the kidney and inner ear, playing roles in cell signaling and membrane transport.

Application of CLIC Antibodies

• Ion Channel Research: CLIC antibodies are used to study the mechanisms of chloride ion transport in cells, particularly how CLIC proteins transition between soluble and membrane-bound forms. Researchers use these antibodies to investigate the regulation of intracellular chloride levels, which affect various physiological processes, including cell volume regulation and membrane potential.
• Cancer Research: CLIC proteins, especially CLIC1 and CLIC4, are upregulated in several types of cancer and are involved in cancer cell proliferation, invasion, and metastasis. CLIC antibodies are utilized in cancer studies to investigate how these proteins contribute to tumor growth and progression. For instance, anti-CLIC1 antibodies are employed to explore its role in promoting oxidative stress resistance in cancer cells.
• Apoptosis and Cellular Stress Studies: CLIC4 is involved in regulating apoptosis and cellular responses to oxidative stress. CLIC antibodies are used to examine how CLIC proteins modulate these pathways and their impact on disease development, particularly in cancer and neurodegenerative diseases. These antibodies are also useful in exploring the molecular mechanisms underlying CLIC4’s role in cell death.
• Cardiovascular and Renal Disease Research: CLIC5 plays a role in kidney function and the regulation of hearing, making it an important target for studying kidney and ear disorders. CLIC antibodies are used to investigate how CLIC5 contributes to membrane transport and signaling in these tissues, as well as its involvement in disease processes like hypertension and hearing loss.

CLIC antibodies are vital tools for understanding the roles of chloride intracellular channel proteins in ion transport, apoptosis, cancer progression, and tissue-specific functions in diseases affecting the kidney, cardiovascular system, and nervous system.