CLIC Antibodies

CLIC (Chloride Intracellular Channel) antibodies target the CLIC family of proteins, which are involved in various cellular processes, including ion transport, apoptosis, and membrane trafficking. The CLIC family consists of several members, such as CLIC1, CLIC4, and CLIC5, which can switch between soluble and membrane-bound forms, functioning as chloride channels in both the cytoplasm and on membranes.

Content of CLIC Antibodies

CLIC antibodies are monoclonal or polyclonal antibodies that specifically detect different CLIC proteins. They are used in research to study the expression, localization, and function of CLIC proteins in various tissues.

  • CLIC1: Associated with ion transport and oxidative stress response. It plays a role in cancer cell migration and is implicated in tumor progression.
  • CLIC4: Involved in apoptosis, cytoskeleton remodeling, and oxidative stress regulation. Its dysregulation has been linked to cancer and fibrosis.
  • CLIC5: Primarily found in the kidney and inner ear, playing roles in cell signaling and membrane transport.
Application of CLIC Antibodies
  • Ion Channel Research: CLIC antibodies are used to study the mechanisms of chloride ion transport in cells, particularly how CLIC proteins transition between soluble and membrane-bound forms. Researchers use these antibodies to investigate the regulation of intracellular chloride levels, which affect various physiological processes, including cell volume regulation and membrane potential.
  • Cancer Research: CLIC proteins, especially CLIC1 and CLIC4, are upregulated in several types of cancer and are involved in cancer cell proliferation, invasion, and metastasis. CLIC antibodies are utilized in cancer studies to investigate how these proteins contribute to tumor growth and progression. For instance, anti-CLIC1 antibodies are employed to explore its role in promoting oxidative stress resistance in cancer cells.
  • Apoptosis and Cellular Stress Studies: CLIC4 is involved in regulating apoptosis and cellular responses to oxidative stress. CLIC antibodies are used to examine how CLIC proteins modulate these pathways and their impact on disease development, particularly in cancer and neurodegenerative diseases. These antibodies are also useful in exploring the molecular mechanisms underlying CLIC4’s role in cell death.
  • Cardiovascular and Renal Disease Research: CLIC5 plays a role in kidney function and the regulation of hearing, making it an important target for studying kidney and ear disorders. CLIC antibodies are used to investigate how CLIC5 contributes to membrane transport and signaling in these tissues, as well as its involvement in disease processes like hypertension and hearing loss.

CLIC antibodies are vital tools for understanding the roles of chloride intracellular channel proteins in ion transport, apoptosis, cancer progression, and tissue-specific functions in diseases affecting the kidney, cardiovascular system, and nervous system.


AffiAB®​​ CLIC6 Polyclonal Antibody
CAT# AFG-BTL-02737
Size: 100 uL
382.50 382.5 USD
AffiAB®​​ CLIC5 Rabbit Polyclonal Antibody
CAT# AFG-BTL-02736
Size: 100 uL
382.50 382.5 USD
AffiAB®​​ CLIC4 Polyclonal Antibody
CAT# AFG-BTL-02735
Size: 100 uL
382.50 382.5 USD
AffiAB®​​ CLIC3 Polyclonal Antibody
CAT# AFG-BTL-02734
Size: 100 uL
382.50 382.5 USD
AffiAB®​​ CLIC1 Polyclonal Antibody
CAT# AFG-BTL-02733
Size: 100 uL
382.50 382.5 USD
AffiAB® Anti-CLIC4 Antibody
CAT# AFG-BRB-11635
Size: 100 μL
663.00 663.0 USD
AffiAB® Anti-CLIC5 Purified Monoclonal Antibody
CAT# AFG-BRB-08700
Size: 0.1mg
590.10 590.1 USD
AffiAB® Anti-CLIC3 Antibody
CAT# AFG-BRB-01501
Size: 100 μL
636.00 636.0 USD
AffiAB® Anti-CLIC6 Antibody
CAT# AFG-BRB-01176
Size: 100 μL
636.00 636.0 USD
AffiAB® Human CLIC2 Antibody (Biotin Conjugate)
CAT# AFG-SYP-3040
Size: 150 μg
578.00 578.0 USD
AffiAB® Rabbit Anti-CLIC4 Antibody
CAT# AFG-DDA-5440
Size: 100 μL
308.75 308.75 USD
AffiAB® Rabbit Anti-CLIC4 Antibody
CAT# AFG-DDA-4925
Size: 100 μL
308.75 308.75 USD
AffiAB® Rabbit anti-CLIC6 Antibody
CAT# AFG-DDA-2707
Size: 100 μL
284.05 284.05 USD
AffiAB® Rabbit anti-CLIC3 Antibody
CAT# AFG-DDA-1206
Size: 100 μL
274.55 274.55 USD
AffiAB® Rabbit anti-CLIC1 Antibody
CAT# AFG-DDA-0632
Size: 100 μL
256.50 256.5 USD
AffiAB® CLIC6 Polyclonal Antibody
CAT# AFG-PAB-02921
Size: 100 µg
Conjugation: Unconjugated
335.50 335.5 USD
AffiAB® CLIC4 Polyclonal Antibody
CAT# AFG-PAB-02920
Size: 100 µg
Conjugation: Unconjugated
335.50 335.5 USD
AffiAB® CLIC3 Polyclonal Antibody
CAT# AFG-PAB-02919
Size: 100 µg
Conjugation: Unconjugated
335.50 335.5 USD
AffiAB® CLIC2 Polyclonal Antibody
CAT# AFG-PAB-02918
Size: 100 µg
Conjugation: Unconjugated
533.50 533.5 USD
AffiAB® CLIC1 Polyclonal Antibody
CAT# AFG-PAB-02917
Size: 150 µL
Conjugation: Unconjugated
1,112.50 1112.5 USD
AffiAB® Rabbit anti-CLIC6 Antibody
CAT# AFG-YBP-2160
Size: 100 µL
457.00 457.0 USD
AffiAB® Rabbit anti-CLIC4 Antibody
CAT# AFG-YBP-2159
Size: 100 µL
457.00 457.0 USD
AffiAB® Rabbit anti-CLIC4 Antibody
CAT# AFG-YBP-2158
Size: 100 µL
457.00 457.0 USD
AffiAB® Rabbit anti-CLIC3 Antibody
CAT# AFG-YBP-2157
Size: 100 µL
457.00 457.0 USD
AffiAB® Rabbit anti-CLIC1 Antibody
CAT# AFG-YBP-2156
Size: 100 µL
457.00 457.0 USD
AffiAB® Anti-CLIC5 PE [CLIC5-02]
CAT# AFG-EXB-1604
Size: 100 Tests
281.00 281.0 USD
AffiAB® Anti-CLIC5 Purified [CLIC5-02]
CAT# AFG-EXB-0505
Size: 0.1 mg
239.00 239.0 USD
AffiAB® CLIC6 Antibody
CAT# AFG-IVA-06625
Size: 25 µL
Terminal: Middle region
378.95 378.95 USD
AffiAB® CLIC5 Antibody
CAT# AFG-IVA-06624
Size: 0.1 mg
Terminal: N/A
624.65 624.65 USD
AffiAB® CLIC4 Antibody
CAT# AFG-IVA-06623
Size: 100 µg
Terminal: N/A
719.15 719.15 USD
AffiAB® CLIC3 Antibody
CAT# AFG-IVA-06622
Size: 100 µg
Terminal: N/A
719.15 719.15 USD
AffiAB® CLIC2 Antibody
CAT# AFG-IVA-06621
Size: 100 µg
Terminal: N/A
705.65 705.65 USD
AffiAB® CLIC1 Antibody
CAT# AFG-IVA-06619
Size: 100 µL
Terminal: N/A
611.15 611.15 USD
AffiAB® CLIC4 Rabbit Polyclonal Antibody
CAT# AFG-EKA-07812
Size: 100 µL
246.00 246.0 USD
AffiAB® CLIC1 Rabbit Polyclonal Antibody
CAT# AFG-EKA-07811
Size: 100 µL
246.00 246.0 USD
AffiAB® CLIC3 Rabbit Polyclonal Antibody
CAT# AFG-EKA-07439
Size: 100 µL
246.00 246.0 USD
AffiAB® CLIC6 Rabbit Polyclonal Antibody
CAT# AFG-EKA-06141
Size: 100 µL
246.00 246.0 USD
AffiAB® CLIC4 Rabbit Polyclonal Antibody
CAT# AFG-EKA-01501
Size: 100 µL
246.00 246.0 USD
AffiAB® CLIC4 Rabbit Polyclonal Antibody
CAT# AFG-EKA-00423
Size: 100 µL
246.00 246.0 USD
AffiAB® CLIC1 Rabbit Polyclonal Antibody
CAT# AFG-EKA-00422
Size: 100 µL
246.00 246.0 USD