Glypican-3 Antibodies

Gene Name: Glypican-3 (GPC3)

Function:

  • Glypican-3 is a cell surface heparan sulfate proteoglycan involved in various cellular processes, including cell growth, proliferation, and differentiation.
  • It interacts with signaling molecules and modulates pathways such as the Wnt/β-catenin pathway, contributing to cell signaling and tissue development.
  • Dysregulation of Glypican-3 expression or activity may influence tumor growth, metastasis, and angiogenesis in cancer.

Immune Regulation:

  • Glypican-3 expression on tumor cells may influence immune responses within the tumor microenvironment.
  • Tumors expressing Glypican-3 may exhibit immunosuppressive characteristics, such as increased expression of immune checkpoint molecules or recruitment of regulatory immune cell populations.
  • Targeting Glypican-3-positive tumor cells with immunotherapeutic approaches, such as vaccines or CAR-T cell therapies, aims to enhance anti-tumor immune responses and overcome immunosuppression.

Apoptosis:

  • While the direct role of Glypican-3 in apoptosis regulation is not fully understood, dysregulation of Glypican-3 expression or activity may impact apoptotic signaling pathways, contributing to cancer cell survival and tumor progression.

Research Implications:

  • Understanding the functions of Glypican-3 is essential for elucidating its roles in development, tissue homeostasis, and disease.
  • Research on Glypican-3 may have implications for various fields, including cancer biology, regenerative medicine, and immunotherapy.

Clinical Relevance:

  • Dysregulation of Glypican-3 expression is associated with various cancers, including hepatocellular carcinoma (HCC) and other malignancies.
  • Investigating Glypican-3's role as a diagnostic marker or therapeutic target may provide insights into disease mechanisms and treatment strategies.
  • Glypican-3-targeted therapies, such as monoclonal antibodies or antibody-drug conjugates, are being developed and evaluated in clinical trials for the treatment of Glypican-3-positive cancers. These therapies hold promise for improving patient outcomes and overcoming treatment resistance.
399.50 399.5 USD
AffiAB® Anti-Glypican-3 Antibody
CAT# AFG-BMG-3117
Size: 100 µg
138.25 138.25 USD
AffiAB® Anti Human GPC3 Polyclonal Antibody
CAT# AFG-BMG-1170
Size: 100 µl
527.28 527.28 USD
AffiAB® Glypican-3 Antibody
CAT# AFG-BMG-0186
Size: 0.1 mL
156.97 156.97 USD
AffiAB®​​ GPC39 Polyclonal Antibody
CAT# AFG-BTL-05509
Size: 100 uL
271.25 271.25 USD
AffiAB®​​ Glypican-3 Polyclonal Antibody
CAT# AFG-BTL-05434
Size: 100 uL
271.25 271.25 USD
624.55 624.5500000000001 USD
624.55 624.5500000000001 USD
624.55 624.5500000000001 USD
624.55 624.5500000000001 USD
420.00 420.0 USD
380.00 380.0 USD
380.00 380.0 USD
380.00 380.0 USD
380.00 380.0 USD
380.00 380.0 USD
380.00 380.0 USD
380.00 380.0 USD
380.00 380.0 USD
AffiAB®​ Glypican-3 (GPC3/863), 1mg/mL Antibody
CAT# AFG-BTM-05149
Size: 50 μL
624.55 624.5500000000001 USD
AffiAB®​ Glypican-3 (GPC3/863), 0.2mg/mL Antibody
CAT# AFG-BTM-05148
Size: 100 μL
420.00 420.0 USD
380.00 380.0 USD
380.00 380.0 USD
380.00 380.0 USD
380.00 380.0 USD
380.00 380.0 USD
380.00 380.0 USD
380.00 380.0 USD
AffiAB®​ Glypican-3 (1G12), 1mg/mL Antibody
CAT# AFG-BTM-05140
Size: 50 μL
624.55 624.5500000000001 USD
AffiAB®​ Glypican-3 (1G12), 0.2mg/mL Antibody
CAT# AFG-BTM-05139
Size: 100 μL
420.00 420.0 USD
380.00 380.0 USD
380.00 380.0 USD
380.00 380.0 USD
380.00 380.0 USD
380.00 380.0 USD
380.00 380.0 USD
380.00 380.0 USD
AffiAB® Anti-Glypican-3 GPC3 Antibody
CAT# AFG-BRB-02772
Size: 100 μL
389.05 389.05 USD
399.50 399.5 USD
AffiAB® Rabbit anti-Glypican 3 Antibody
CAT# AFG-DDA-3229
Size: 100 μL
284.05 284.05 USD
AffiAB® GPC3 Polyclonal Antibody
CAT# AFG-PAB-05836
Size: 100 µg
Conjugation: Unconjugated
267.00 267.0 USD
AffiAB® Rabbit anti-Glypican 3 Antibody
CAT# AFG-YBP-3672
Size: 100 µL
457.00 457.0 USD
AffiAB® GPC3 Antibody
CAT# AFG-IVA-12379
Size: 100 µg
Terminal: N/A
312.55 312.55 USD
AffiAB® GPC39 Rabbit Polyclonal Antibody
CAT# AFG-EKA-11239
Size: 100 µL
210.80 210.8 USD
AffiAB® Glypican-3 Rabbit Polyclonal Antibody
CAT# AFG-EKA-03441
Size: 100 µL
210.80 210.8 USD