CD123 Antibodies

Gene Name: CD123 (Cluster of Differentiation 123)

Function: CD123, also known as interleukin-3 receptor alpha chain (IL-3Rα), is a cell surface protein that serves as a subunit of the interleukin-3 receptor complex. It is primarily expressed on hematopoietic stem cells and progenitor cells, as well as on certain immune cell subsets, including dendritic cells and basophils. CD123 plays a crucial role in hematopoiesis, immune cell development, and immune responses.

Immune Regulation: CD123 is involved in regulating immune cell development and function, particularly in the context of myeloid cell differentiation and dendritic cell maturation. It serves as a receptor for interleukin-3 (IL-3), a cytokine that regulates the proliferation, survival, and differentiation of hematopoietic cells. CD123 signaling influences the development and activation of myeloid lineage cells and contributes to immune responses against pathogens and antigens.

Apoptosis: While CD123 itself does not directly induce apoptosis, dysregulation of CD123 signaling can affect hematopoietic cell survival and contribute to the pathogenesis of certain hematological malignancies. Aberrant CD123 expression or activation has been observed in acute myeloid leukemia (AML), acute lymphoblastic leukemia (ALL), and other hematopoietic disorders, suggesting a potential role in apoptosis regulation in these diseases.

Research Implications: Understanding the functions of CD123 is important for elucidating its roles in hematopoiesis, immune regulation, and hematological diseases. Research on CD123 signaling pathways may have implications for the development of therapies targeting hematopoietic-related diseases and immune disorders.

Clinical Relevance: CD123 has emerged as a therapeutic target for the treatment of hematological malignancies, particularly AML and ALL. Monoclonal antibodies targeting CD123, such as tagraxofusp (SL-401) and flotetuzumab, have been developed for the treatment of CD123-positive leukemias. Additionally, CD123-directed CAR-T cell therapies are being investigated for the treatment of CD123-positive AML and ALL.



AffiAB® CD123 Antibody
CAT# AFG-BMG-0167
Size: 0.1 mL
131.03 131.03 USD
AffiAB®​​ CD123 Polyclonal Antibody
CAT# AFG-BTL-01905
Size: 100 uL
271.25 271.25 USD
624.55 624.5500000000001 USD
624.55 624.5500000000001 USD
624.55 624.5500000000001 USD
399.50 399.5 USD
286.45 286.45 USD
AffiAB® Rabbit anti-CD123 Antibody
CAT# AFG-DDA-2256
Size: 100 μL
284.05 284.05 USD
AffiAB® Rabbit anti-CD123 Antibody
CAT# AFG-YBP-1536
Size: 100 µL
457.00 457.0 USD
AffiAB® Anti-Hu CD123 PerCP-Cy5.5 [6H6]
CAT# AFG-EXB-2334
Size: 100 Tests
285.00 285.0 USD
AffiAB® Anti-Hu CD123 PE-Cy5 [6H6]
CAT# AFG-EXB-2277
Size: 100 Tests
209.00 209.0 USD
AffiAB® Anti-Hu CD123 PE-Cy7 [6H6]
CAT# AFG-EXB-2219
Size: 100 Tests
237.00 237.0 USD
AffiAB® Anti-Hu CD123 PerCP [6H6]
CAT# AFG-EXB-2061
Size: 100 Tests
209.00 209.0 USD
AffiAB® Anti-Hu CD123 Pacific Blue [6H6]
CAT# AFG-EXB-2013
Size: 100 Tests
209.00 209.0 USD
AffiAB® Anti-Hu CD123 Alexa Fluor 700 [6H6]
CAT# AFG-EXB-1933
Size: 100 Tests
209.00 209.0 USD
AffiAB® Anti-Hu CD123 Alexa Fluor 647 [6H6]
CAT# AFG-EXB-1873
Size: 100 Tests
209.00 209.0 USD
AffiAB® Anti-Hu CD123 PE [6H6]
CAT# AFG-EXB-1603
Size: 100 Tests
209.00 209.0 USD
AffiAB® Anti-Hu CD123 FITC [6H6]
CAT# AFG-EXB-1316
Size: 100 Tests
171.00 171.0 USD
AffiAB® Anti-Hu CD123 Biotin [6H6]
CAT# AFG-EXB-1115
Size: 0.1 mg
171.00 171.0 USD
AffiAB® Anti-Hu CD123 APC [6H6]
CAT# AFG-EXB-0968
Size: 100 Tests
209.00 209.0 USD
AffiAB® Anti-Hu CD123 Purified [6H6]
CAT# AFG-EXB-0504
Size: 0.1 mg
123.00 123.0 USD
688.00 688.0 USD
AffiAB® PerCP/Cyanine5.5 Anti-Human CD123 Antibody
CAT# AFG-DDF-2213
Size: 100 Tests
547.50 547.5 USD
AffiAB® PE/Cyanine7 Anti-Human CD123 Antibody
CAT# AFG-DDF-1977
Size: 100 Tests
547.50 547.5 USD
AffiAB® PE/Cyanine5.5 Anti-Human CD123 Antibody
CAT# AFG-DDF-1821
Size: 100 Tests
547.50 547.5 USD
AffiAB® PE/Cyanine5 Anti-Human CD123 Antibody
CAT# AFG-DDF-1656
Size: 100 Tests
547.50 547.5 USD
AffiAB® PE Anti-Human CD123 Antibody
CAT# AFG-DDF-1382
Size: 100 Tests
420.00 420.0 USD
AffiAB® Biotin Anti-Human CD123 Antibody
CAT# AFG-DDF-1012
Size: 100 μg
681.00 681.0 USD
400.00 400.0 USD
400.00 400.0 USD
AffiAB® AF647 Anti-Human CD123 Antibody
CAT# AFG-DDF-0280
Size: 100 Tests
547.50 547.5 USD
AffiAB® AF488 Anti-Human CD123 Antibody
CAT# AFG-DDF-0097
Size: 100 Tests
547.50 547.5 USD
AffiAB® CD123 Rabbit Polyclonal Antibody
CAT# AFG-EKA-08621
Size: 100 µL
210.80 210.8 USD