REC Antibodies

REC antibodies are designed to detect and target proteins involved in DNA repair, recombination, and cell cycle regulation, typically those with a RecQ helicase domain or those related to homologous recombination processes. Proteins from the REC family, such as RECQL (RecQ Like Helicase) and RECQL5, play crucial roles in maintaining genome stability by participating in DNA unwinding, replication, repair, and recombination. 

Applications of REC Antibodies

• Western Blotting (WB): REC antibodies are commonly used in western blotting to detect REC proteins, such as RECQL, in cell and tissue lysates. This application helps quantify REC protein expression in different conditions, such as during DNA damage response or in cancerous tissues.
• Immunohistochemistry (IHC): REC antibodies are used in IHC to localize REC proteins in tissue samples, particularly in studies of cancer or aging-related disorders where defects in DNA repair are implicated.
• Flow Cytometry (FC): In flow cytometry, REC antibodies help analyze the expression of REC proteins across different cell populations, particularly in studies of DNA damage response in cancer cells or stem cells.

REC Antibodies in Disease Research

• Cancer Research: REC proteins play a crucial role in preventing genomic instability, which is a hallmark of cancer. Mutations or dysfunctions in REC helicases, such as RECQL and RECQL5, are linked to increased cancer susceptibility. For example, RECQL mutations have been associated with breast cancer and other malignancies. REC antibodies are used in cancer research to study how REC proteins contribute to the DNA repair machinery, genome stability, and tumor suppression.
• Aging and Premature Aging Syndromes: Defects in REC proteins are linked to premature aging syndromes such as Werner syndrome (caused by mutations in the WRN helicase) and Bloom syndrome (caused by mutations in BLM helicase). These syndromes are characterized by increased cancer risk and accelerated aging due to defective DNA repair and recombination. 
• Neurodegenerative Diseases: Genome instability is also implicated in neurodegenerative diseases. Dysfunction in REC proteins involved in DNA repair can contribute to the accumulation of DNA damage in neurons, leading to neurodegeneration. REC antibodies are used in research focused on understanding how DNA repair deficiencies contribute to the onset and progression of these diseases.

REC antibodies are essential tools for exploring the mechanisms of DNA repair, recombination, and genome stability. These antibodies facilitate the study of REC proteins in processes such as DNA replication, repair, and homologous recombination, making them crucial for research in cancer biology, aging, and neurodegenerative diseases.