IMPDH Antibodies

Inosine monophosphate dehydrogenase (IMPDH) is an essential enzyme that plays a key role in the de novo synthesis of guanine nucleotides, particularly guanosine triphosphate (GTP). This enzyme catalyzes the rate-limiting step in the conversion of inosine monophosphate (IMP) to xanthosine monophosphate (XMP), which is further converted to GTP. IMPDH exists in two isoforms, IMPDH1 and IMPDH2, both of which are critical in the regulation of cell proliferation and immune response. IMPDH antibodies are crucial reagents for studying the expression, regulation, and functional activity of IMPDH in biological systems. 

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IMPDH antibodies are highly specific immunological tools used to detect and analyze IMPDH1 and IMPDH2. Depending on the research context, these antibodies can be monoclonal or polyclonal. Monoclonal antibodies provide high specificity by recognizing a single epitope on the IMPDH protein, making them ideal for applications requiring precision and reproducibility. Polyclonal antibodies, which bind to multiple epitopes, can offer higher sensitivity in certain assay formats.

Applications of IMPDH Antibodies

• Antiviral Therapy Research: IMPDH plays a significant role in viral replication because many viruses, such as hepatitis C virus (HCV) and cytomegalovirus (CMV), rely on host cell nucleotide synthesis. IMPDH antibodies are used in research to explore the impact of IMPDH inhibitors on viral replication. 
• Drug Development and Screening: IMPDH antibodies are instrumental in drug discovery, especially in screening for new IMPDH inhibitors that may serve as potential therapeutic agents for cancer, viral infections, and autoimmune diseases. In high-throughput screening assays, IMPDH antibodies are used to evaluate the efficacy of candidate drugs in inhibiting IMPDH activity. 
• Metabolic Disease and Cell Proliferation Studies: The role of IMPDH in purine metabolism makes it a key player in regulating cell proliferation. IMPDH antibodies are employed to study metabolic diseases that result from abnormal nucleotide metabolism. Researchers use these antibodies to measure the levels of IMPDH in tissues or cell lines to investigate how dysregulated nucleotide synthesis contributes to metabolic disorders or aberrant cell proliferation. 
• Signal Transduction Pathway Analysis: IMPDH activity is regulated by cellular signaling pathways that control cell growth and proliferation. IMPDH antibodies are valuable for studying how signaling pathways, such as mTOR and MAPK, influence IMPDH expression and function. 

IMPDH antibodies are essential tools for studying the regulation and function of IMPDH in a variety of biological systems. They provide valuable insights into IMPDH-related processes in cancer, immunology, antiviral therapy, and metabolic diseases. These antibodies are widely used in applications such as Western blotting, immunohistochemistry, ELISA, and flow cytometry to detect and quantify IMPDH expression and activity, contributing to the development of novel therapeutics targeting IMPDH.