![AffiAB® Anti-IMPDH2 Antibody [JE40-87]](/web/image/product.product/74875/image_1024/%5BAFG-HB-2102%5D%20AffiAB%C2%AE%20Anti-IMPDH2%20Antibody%20%5BJE40-87%5D%20?unique=d31c23b)
AffiAB® Anti-IMPDH2 Antibody [JE40-87]
Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP) , the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. Could also have a single-stranded nucleic acid-binding activity and could play a role in RNA and/or DNA metabolism. It may also have a role in the development of malignancy and the growth progression of some tumors.
Antibody type
Recombinant Rabbit monoclonal Antibody
Uniprot ID
SwissProt: P12268 Human; SwissProt: P24547 Mouse; SwissProt: E9PU28 Rat
Recombinant
YES
Conjugation
Non-conjugated
Host
Rabbit
Isotype
IgG
Clone
JE40-87
KO/KD
N/A
Species reactivity
Human, Mouse, Rat
Tested applications
WB, IF-Cell, IF-Tissue, IHC-P, FC, IP
Predicted species reactivity
N/A
Immunogen
Recombinant protein within Human IMPDH2 aa 80-320 / 514.
Storage
Store at +4°C after thawing. Aliquot store at -20°C. Avoid repeated freeze / thaw cycles.
Form
Liquid
Storage buffer
1*TBS (pH7.4) , 0.05% BSA, 40% Glycerol. Preservative: 0.05% Sodium Azide.
Concentration
1 mg/mL.
Purity
Protein A affinity purified.
Signal pathway
N/A
Recommended dilutions
WB: 1:500-1:2, 000; IF-Cell: 1:50-1:200; IF-Tissue: 1:50-1:200; IHC-P: 1:50-1:200; FC: 1:10-1:50; IP: 1:10-1:50
Molecular Weight
56 kDa
Subcellular location
Nucleus. Cytoplasm.
Positive control
Daudi cell lysate, A431 cell lysate, A431, LOVO, PC-3M, rat kidney tissue, human tonsil tissue, human thyroid tissue, mouse testis tissue, Daudi.