![AffiAB® Anti-Hu CD335 PE [9E2]](/web/image/product.product/292123/image_1024/%5BAFG-XBO-1243%5D%20AffiAB%C2%AE%E2%80%8B%20Anti-Hu%20CD335%20PE%20%5B9E2%5D?unique=d31c23b)
Overview
CD335 is a type I transmembrane glycoprotein, which serves as one of natural cytotoxicity receptors, and represents major receptor informing NK cells that they should kill particular virus-infected or tumor cell. Its sialic acids residues are involved in recognition of viral hemagglutinins, similarly it recognizes heparan sulphate proteoglycans on the surface of tumor cells. CD335 transfers the signal downstream via association with CD3 zeta chain, that contains intracellular ITAM motifs. Expression of CD335, a specific marker of NK cells (both resting and activated), is down regulated by cortisol, and up-regulated by prolactin..
Species Reactivity
Human.
Antigen
CD335.
Negative Species
N/A.
Application
FC (QC tested) ) .
Immunogen
fusion protein of human CD335 and Fc part of IgG.
Clone
9E2.
Format
PE.
Isotype
Mouse IgG1.
Storage Buffer
Stabilizing phosphate buffered saline (PBS), pH 7.4, 15 mM sodium azide.
Storage & Stability
Store at 2-8°C. Protect from prolonged exposure to light. Do not freeze.