![AffiAB® Anti-Hu CD33 Pacific Blue [WM53]](/web/image/product.product/292112/image_1024/%5BAFG-XBO-1232%5D%20AffiAB%C2%AE%E2%80%8B%20Anti-Hu%20CD33%20Pacific%20Blue%20%5BWM53%5D?unique=d31c23b)
Overview
CD33 is a transmembrane protein of the sialic acid-binding immunoglobulin-like lectin (Siglec) family. It belongs to the immunoreceptor tyrosine-based inhibitory motif (ITIM) -containing molecules able of recruiting protein tyrosine phosphatases SHP-1 and SHP-2 to signal assemblies; these ITIMs are also used for ubiquitin-mediated removal of the receptor from the cell surface. CD33 is expressed on cells of myelomonocytic lineage, binds sialic acid residues in N- and O-glycans on cell surfaces, and is a therapeutic target for acute myeloid leukemia..
Species Reactivity
Non-human primates, Human.
Antigen
CD33.
Negative Species
N/A.
Application
FC (QC tested) ) .
Immunogen
Human AML cells.
Clone
WM53.
Format
Pacific Blue.
Isotype
Mouse IgG1.
Storage Buffer
Stabilizing phosphate buffered saline (PBS), pH 7.4, 15 mM sodium azide.
Storage & Stability
Store at 2-8°C. Protect from prolonged exposure to light. Do not freeze.