![AffiAB® Anti-Progesterone Receptor Antibody [JF0549]](/web/image/product.product/77705/image_1024/%5BAFG-HB-3247%5D%20AffiAB%C2%AE%20Anti-Progesterone%20Receptor%20Antibody%20%5BJF0549%5D%20?unique=a48b62f)
AffiAB® Anti-Progesterone Receptor Antibody [JF0549]
PR, a protein with 946 amino acids, is a ligand-activated transcription factor member of the steroid receptor super family of nuclear receptors. The functional structure is similar to that of estrogen receptor (ER) , with considerable sequence homology in the DNA-binding central domain. PR is predominantly expressed in tumours of female sex steroid responsive tissues such as the mammary gland, endometrium and the ovary. About half of the breast carcinomas are ER+/PR+. A small fraction (
Antibody type
Recombinant Rabbit monoclonal Antibody
Uniprot ID
SwissProt: P06401 Human
Recombinant
YES
Conjugation
Non-conjugated
Host
Rabbit
Isotype
IgG
Clone
JF0549
KO/KD
N/A
Species reactivity
Human
Tested applications
WB, IF-Cell, IF-Tissue, IHC-P, IP
Predicted species reactivity
N/A
Immunogen
Synthetic peptide within N-terminal human Progesterone Receptor.
Storage
Store at +4°C after thawing. Aliquot store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.
Form
Liquid
Storage buffer
1*TBS (pH7.4) , 0.05% BSA, 40% Glycerol. Preservative: 0.05% Sodium Azide.
Concentration
1 mg/mL.
Purity
Protein A affinity purified.
Signal pathway
Cancer
Recommended dilutions
WB: 1:1, 000; IF-Cell: 1:50-1:100; IF-Tissue: 1:50-1:100; IHC-P: 1:50-1:200; IP: Use at an assay dependent concentration.
Molecular Weight
99 kDa
Subcellular location
Nucleus, Cytoplasm, Mitochondrion outer membrane.
Positive control
MCF-7, human breast tissue, human cervix tissue, human uterus tissue, human smooth muscle tissue.