![AffiAB® Anti-MMP17 Antibody [JU33-03]](/web/image/product.product/77010/image_1024/%5BAFG-HB-2503%5D%20AffiAB%C2%AE%20Anti-MMP17%20Antibody%20%5BJU33-03%5D%20?unique=d31c23b)
AffiAB® Anti-MMP17 Antibody [JU33-03]
Endopeptidase that degrades various components of the extracellular matrix, such as fibrin. May be involved in the activation of membrane-bound precursors of growth factors or inflammatory mediators, such as tumor necrosis factor-alpha. May also be involved in tumoral process. Cleaves pro-TNF-alpha at the '74-Ala-|-Gln-75' site. Not obvious if able to proteolytically activate progelatinase A. Does not hydrolyze collagen types I, II, III, IV and V, gelatin, fibronectin, laminin, decorin nor alpha1-antitrypsin.
Antibody type
Recombinant Rabbit monoclonal Antibody
Uniprot ID
SwissProt: Q9ULZ9 Human; SwissProt: Q9R0S3 Mouse
Recombinant
YES
Conjugation
Non-conjugated
Host
Rabbit
Isotype
IgG
Clone
JU33-03
KO/KD
N/A
Species reactivity
Human, Mouse, Rat
Tested applications
IF-Cell, IF-Tissue, IHC-P, WB
Predicted species reactivity
N/A
Immunogen
Recombinant protein within Human MMP17 aa 175-225 / 603.
Storage
Store at +4°C after thawing. Aliquot store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.
Form
Liquid
Storage buffer
1*TBS (pH7.4) , 0.05% BSA, 40% Glycerol. Preservative: 0.05% Sodium Azide.
Concentration
1 mg/mL.
Purity
Protein A affinity purified.
Signal pathway
N/A
Recommended dilutions
IF-Cell: 1:50; IHC-P: 1:50; WB: 1:500
Molecular Weight
67 kDa
Subcellular location
Secreted. Plasma membrane.
Positive control
A549, MCF-7, mouse brain tissue.