![AffiAB® Anti-Leptin Receptor Antibody [JA73-01]](/web/image/product.product/76821/image_1024/%5BAFG-HB-2306%5D%20AffiAB%C2%AE%20Anti-Leptin%20Receptor%20Antibody%20%5BJA73-01%5D%20?unique=a48b62f)
AffiAB® Anti-Leptin Receptor Antibody [JA73-01]
Receptor for obesity factor (leptin) . On ligand binding, mediates signaling through JAK2/STAT3. Involved in the regulation of fat metabolism and, in a hematopoietic pathway, required for normal lymphopoiesis. May play a role in reproduction. Can also mediate the ERK/FOS signaling pathway.
Antibody type
Recombinant Rabbit monoclonal Antibody
Uniprot ID
SwissProt: P48357 Human; SwissProt: P48356 Mouse; SwissProt: Q62959 Rat
Recombinant
YES
Conjugation
Non-conjugated
Host
Rabbit
Isotype
IgG
Clone
JA73-01
KO/KD
N/A
Species reactivity
Human, Mouse, Rat
Tested applications
WB, IF-Cell, IHC-P, FC
Predicted species reactivity
N/A
Immunogen
Synthetic peptide within Human Leptin Receptor aa 1041-1090 / 1165.
Storage
Store at +4°C after thawing. Aliquot store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.
Form
Liquid
Storage buffer
1*TBS (pH7.4) , 0.05% BSA, 40% Glycerol. Preservative: 0.05% Sodium Azide.
Concentration
1 mg/mL.
Purity
Protein A affinity purified.
Signal pathway
Immunology & Inflammation, JAK-STAT signaling pathway, Cardiovascular, AMPK signaling pathway
Recommended dilutions
WB: 1:500-1:2, 000; IF-Cell: 1:50-1:100; IHC-P: 1:50-1:1, 000; FC: 1:50-1:100
Molecular Weight
Predicted band size: 132 kDa
Subcellular location
Cell membrane, Basolateral cell membrane.
Positive control
Mouse lung tissue lysate, mouse liver tissue lysate, HepG2 cell lysates, MCF-7, rat heart tissue, human liver carcinoma tissue, human prostate tissue, human kidney tissue, mouse small intestine tissue, K562.