![AffiAB® Anti-IP3 Receptor Antibody [JA11-35]](/web/image/product.product/74913/image_1024/%5BAFG-HB-2144%5D%20AffiAB%C2%AE%20Anti-IP3%20Receptor%20Antibody%20%5BJA11-35%5D%20?unique=a48b62f)
AffiAB® Anti-IP3 Receptor Antibody [JA11-35]
Intracellular channel that mediates calcium release from the endoplasmic reticulum following stimulation by inositol 1, 4, 5-trisphosphate. Involved in the regulation of epithelial secretion of electrolytes and fluid through the interaction with AHCYL1. Plays a role in ER stress-induced apoptosis. Cytoplasmic calcium released from the ER triggers apoptosis by the activation of CaM kinase II, eventually leading to the activation of downstream apoptosis pathways.
Antibody type
Recombinant Rabbit monoclonal Antibody
Uniprot ID
SwissProt: Q14643 Human; SwissProt: P11881 Mouse; SwissProt: P29994 Rat
Recombinant
YES
Conjugation
Non-conjugated
Host
Rabbit
Isotype
IgG
Clone
JA11-35
KO/KD
N/A
Species reactivity
Mouse, Rat
Tested applications
WB, IHC-P
Predicted species reactivity
Human
Immunogen
Recombinant protein within Human IP3 Receptor aa 2190-2280 / 2758.
Storage
Store at +4°C after thawing. Aliquot store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.
Form
Liquid
Storage buffer
1*TBS (pH7.4) , 0.05% BSA, 40% Glycerol. Preservative: 0.05% Sodium Azide.
Concentration
1 mg/mL.
Purity
Protein A affinity purified.
Signal pathway
Huntington's disease, Neuroscience, 衰老, Calcium signaling pathway, Immunology & Inflammation, Autophagy Alzheimer disease, Apotosis, Phosphatidylinositol signaling, Parkinson’s disease, cGMP-PKG signaling pathway
Recommended dilutions
WB: 1:500
; IHC-P: 1:50-1:200
Molecular Weight
314 kDa
Subcellular location
Endoplasmic reticulum membrane, secretory vesicle membrane, perinuclear region.
Positive control
Rat cerebellum tissue, mouse cerebellum tissue.