AffiAB® Anti-IP3 Receptor Antibody
Intracellular channel that mediates calcium release from the endoplasmic reticulum following stimulation by inositol 1, 4, 5-trisphosphate. Involved in the regulation of epithelial secretion of electrolytes and fluid through the interaction with AHCYL1. Plays a role in ER stress-induced apoptosis. Cytoplasmic calcium released from the ER triggers apoptosis by the activation of CaM kinase II, eventually leading to the activation of downstream apoptosis pathways.
Antibody type
Rabbit polyclonal Antibody
Uniprot ID
SwissProt: Q14643 Human; SwissProt: P11881 Mouse; SwissProt: P29994 Rat
Recombinant
NO
Conjugation
Non-conjugated
Host
Rabbit
Isotype
IgG
Clone
N/A
KO/KD
N/A
Species reactivity
Human, Mouse, Rat
Tested applications
WB, IHC-P, FC
Predicted species reactivity
N/A
Immunogen
Synthetic peptide within C-terminal human IP3 Receptor.
Storage
Store at +4°C after thawing. Aliquot store at -20°C. Avoid repeated freeze / thaw cycles.
Form
Liquid
Storage buffer
1*PBS (pH7.4) , 0.2% BSA, 50% Glycerol. Preservative: 0.05% Sodium Azide.
Concentration
1 mg/mL.
Purity
Immunogen affinity purified.
Signal pathway
Huntington's disease, Neuroscience, 衰老, Calcium signaling pathway, Immunology & Inflammation, Autophagy Alzheimer disease, Apotosis, Phosphatidylinositol signaling, Parkinson’s disease, cGMP-PKG signaling pathway
Recommended dilutions
WB: 1:500-1:1, 000
; IHC-P: 1:50-1:600
; FC: 1:50-1:100
Molecular Weight
Predicted band size: 314 kDa
Subcellular location
Cytoplasm. Cytoplasmic vesicle. Endoplasmic reticulum. Membrane.
Positive control
Hela, rat brain tissue, mouse brain tissue, SH-SY-5Y.