![AffiAB® Anti-Insulin Receptor R Antibody [JM22-38]](/web/image/product.product/74888/image_1024/%5BAFG-HB-2115%5D%20AffiAB%C2%AE%20Anti-Insulin%20Receptor%20R%20Antibody%20%5BJM22-38%5D%20?unique=a48b62f)
AffiAB® Anti-Insulin Receptor R Antibody [JM22-38]
Insulin receptor-related protein is a protein that in humans is encoded by the INSRR gene. Receptor with tyrosine-protein kinase activity. Functions as a pH sensing receptor which is activated by increased extracellular pH. Activates an intracellular signaling pathway that involves IRS1 and AKT1/PKB.
Antibody type
Recombinant Rabbit monoclonal Antibody
Uniprot ID
SwissProt: P14616 Human; SwissProt: Q9WTL4 Mouse; SwissProt: Q64716 Rat
Recombinant
YES
Conjugation
Non-conjugated
Host
Rabbit
Isotype
IgG
Clone
JM22-38
KO/KD
N/A
Species reactivity
Human, Mouse
Tested applications
WB, IHC-P
Predicted species reactivity
Rat
Immunogen
Synthetic peptide within Human Insulin Receptor R aa 12-61 / 1, 297.
Storage
Store at +4°C after thawing. Aliquot store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.
Form
Liquid
Storage buffer
1*TBS (pH7.4) , 0.05% BSA, 40% Glycerol. Preservative: 0.05% Sodium Azide.
Concentration
1 mg/mL.
Purity
Protein A affinity purified.
Signal pathway
N/A
Recommended dilutions
WB: 1:500
; IHC-P: 1:50-1:200
Molecular Weight
Predicted band size: 144 kDa
Subcellular location
Membrane.
Positive control
Human liver carcinoma tissue, human colon carcinoma tissue, human kidney tissue, mouse testis tissue, mouse kidney tissue.