AffiAB® Anti-IL-2 receptor alpha Antibody
Interleukin-2 receptor alpha chain (also called CD25) is a protein that in humans is encoded by the IL2RA gene.The interleukin 2 (IL2) receptor alpha (IL2RA) and beta (IL2RB) chains, together with the common gamma chain (IL2RG) , constitute the high-affinity IL2 receptor. Homodimeric alpha chains (IL2RA) result in low-affinity receptor, while homodimeric beta (IL2RB) chains produce a medium-affinity receptor. Normally an integral-membrane protein, soluble IL2RA has been isolated and determined to result from extracellular proteolysis. Alternately-spliced IL2RA mRNAs have been isolated, but the significance of each is currently unknown.
Antibody type
Rabbit polyclonal Antibody
Uniprot ID
SwissProt: P01589 Human; SwissProt: P26897 Rat
Recombinant
NO
Conjugation
Non-conjugated
Host
Rabbit
Isotype
IgG
Clone
N/A
KO/KD
N/A
Species reactivity
Human, Rat
Tested applications
WB
Predicted species reactivity
N/A
Immunogen
Synthetic peptide within human IL-2 receptor alpha aa 22-70 (Extracellular domain) .
Storage
Store at +4°C after thawing. Aliquot store at -20°C. Avoid repeated freeze / thaw cycles.
Form
Liquid
Storage buffer
1*TBS (pH7.4) , 0.2% BSA, 50% Glycerol. Preservative: 0.05% Sodium Azide.
Concentration
1 mg/mL.
Purity
Immunogen affinity purified.
Signal pathway
Immunology & Inflammation, JAK-STAT signaling pathway, PI3K-AKT
Recommended dilutions
WB: 1:500-1:1, 000
Molecular Weight
Predicted band size: 31 kDa.
Subcellular location
Membrane.
Positive control
Human kidney tissue lysate, rat spleen tissue lysate.