AffiAB® Anti-GABA A Receptor alpha 6 Antibody
Gamma-aminobutyric acid receptor subunit alpha-6 is a protein that in humans is encoded by the GABRA6 gene. GABA is the major inhibitory neurotransmitter in the mammalian brain where it acts at GABA-A receptors, which are ligand-gated chloride channels. Chloride conductance of these channels can be modulated by agents such as benzodiazepines that bind to the GABA-A receptor. At least 16 distinct subunits of GABA-A receptors have been identified. One study has found a genetic variant in the gene to be associated with the personality trait neuroticism.
Antibody type
Rabbit polyclonal Antibody
Uniprot ID
SwissProt: Q16445 Human; SwissProt: P16305 Mouse; SwissProt: P30191 Rat
Recombinant
NO
Conjugation
Non-conjugated
Host
Rabbit
Isotype
IgG
Clone
N/A
KO/KD
N/A
Species reactivity
Human, Mouse, Rat
Tested applications
WB, IHC-P
Predicted species reactivity
N/A
Immunogen
Recombinant protein within human GABA A Receptor alpha 6 aa 43-242 / 453.
Storage
Store at +4°C after thawing. Aliquot store at -20°C. Avoid repeated freeze / thaw cycles.
Form
Liquid
Storage buffer
1*TBS (pH7.4) , 0.2% BSA, 50% Glycerol. Preservative: 0.05% Sodium Azide.
Concentration
1 mg/mL.
Purity
Immunogen affinity purified.
Signal pathway
N/A
Recommended dilutions
WB: 1:500-1:2, 000
; IHC-P: 1:100-1:500
Molecular Weight
51 kDa
Subcellular location
Postsynaptic cell membrane, Cell membrane.
Positive control
Jurkat cell lysate, PC-3 cell lysate, rat testis tissue lysates, rat testis tissue, rat brain tissue, mouse brain tissue.