![AffiAB® Anti-Hu CD123 PE-Cy5 [6H6]](/web/image/product.product/83776/image_1024/%5BAFG-EXB-2277%5D%20AffiAB%C2%AE%20Anti-Hu%20CD123%20PE-Cy5%20%5B6H6%5D?unique=d31c23b)
Overview
CD123 is the alpha chain of interleukin 3 receptor (IL-3R alpha) . This subunit heterodimerizes with the interleukin 3 receptor beta chain (CD131), which is shared with other receptors. CD123 interacts with IL-3 specifically, but with low affinity, and association with the beta subunit confers high affinity binding to the receptor heterodimer. Both chains are required for signaling, but receptor activation and signal transduction depend on IL-3 binding to CD123 as the initial step.
Specificity:
The mouse monoclonal antibody 6H6 recognizes an extracellular epitope of CD123 (interleukin 3 receptor alpha), a 60-70 kDa transmembrane protein expressed by myeloid precursors, megakaryocytes, macrophages, dendritic cells, mast cells, basophils, and some B cells. This antibody does not inhibit IL-3 binding to its receptor.
Antigen
CD123
Clone
6H6
Species Reactivity
Human
Negative Species
N/A
Isotype
Mouse IgG1
Immunogen
IL3 receptor alpha chain expressed on the surface of transiently transfected COS cells
Application
FC (QC tested)
Regulatory status
RUO
Concentration
N/A
Format
PE-Cy5
Storage / Stability
Store at 2-8°C. Protect from prolonged exposure to light. Do not freeze.
Storage Buffer
Stabilizing phosphate buffered saline (PBS), pH 7.4, 15 mM sodium azide