![AffiAB® Anti-TNF alpha PE [MAb11]](/web/image/product.product/83093/image_1024/%5BAFG-EXB-1594%5D%20AffiAB%C2%AE%20Anti-TNF%20alpha%20PE%20%5BMAb11%5D?unique=d31c23b)
Overview
TNF-alpha is a cytokine produced by monocytes, macrophages, neutrophils, NK cells, CD4+ T cells and many transformed cells. It can be expressed as a 17 kDa free molecule, or as a 26 kDa membrane protein. TNF-alpha easily forms stable trimers, but also other multimeric complexes. In the immune system, it is an important regulator, which has cytolytic and cytostatic activity against a range of tumor cells, increases fibroblast proliferation and supports neutrophil chemotaxis and phagocytosis.
Specificity:
The mouse monoclonal antibody MAb11 recognizes human 17-26 kDa cytokine TNF-alpha (tumor necrosis factor alpha) .
Antigen
TNF alpha
Clone
MAb11
Species Reactivity
Pig, Human, Non-human primates
Negative Species
N/A
Isotype
Mouse IgG1 kappa
Immunogen
Recombinant human TNF-alpha
Application
FC (QC tested)
Regulatory status
RUO
Concentration
N/A
Format
PE
Storage / Stability
Store at 2-8°C. Protect from prolonged exposure to light. Do not freeze.
Storage Buffer
Stabilizing phosphate buffered saline (PBS) , pH 7.4, 15 mM sodium azide