![AffiAB® Anti-TNAP APC [W8B2B10]](/web/image/product.product/79973/image_1024/%5BAFG-EXB-1003%5D%20AffiAB%C2%AE%20Anti-TNAP%20APC%20%5BW8B2B10%5D?unique=0daa593)
Overview
Tissue non-specific alkaline phosphatase (TNAP), also known as liver/bone/kidney alkaline phosphatase, or MSCA-1 (mesenchymal stem cell antigen 1) is a selective marker for the prospective isolation of bone marrow-derived mesenchymal stem cells and mesenchymal stem-like cells. It is expressed at high levels in liver, bone, kidney, or endometrium, as well as on embryonic stem cells (ESCs) . TNAP also plays a role in bone mineralization. Mutations in TNAP gene are associated with hypercalcemia and skeletal defects (hypophosphatasia) .
Specificity:
The mouse monoclonal antibody W8B2B10 recognizes TNAP (tissue non-specific alkaline phosphatase), an ectoenzyme expressed mainly on embryonic stem cells, liver, bone, and kidney cells. This antibody is suitable for characterization of bone marrow-derived MSCs, iPSCs, and ESCs.
Antigen
TNAP
Clone
W8B2B10
Species Reactivity
Dog, Pig, Sheep, Monkey, Goat, Human
Negative Species
N/A
Isotype
Mouse IgG1
Immunogen
WERI-RB-1 retinoblastoma cell line
Application
FC (QC tested)
Regulatory status
RUO
Concentration
0.1 mg/ml
Format
APC
Storage / Stability
Store at 2-8°C. Protect from prolonged exposure to light. Do not freeze.
Storage Buffer
Stabilizing phosphate buffered saline (PBS), pH 7.4, 15 mM sodium azide