AffiAB® PE Anti-Mouse TCR γ/δ Antibody

Background

T cell receptor (TCR) is a heterodimer consisting of an α and a β chain (TCR α/β) or a γ and a δ chain (TCR γ/δ). TCR γ/δ belongs to the immunoglobulin superfamily, involved in the recognition of certain bacterial and tumor Antigens bound to MHC class I. The TCR γ/δ associates with CD3 and is expressed on a T cell subset found in the thymus, the intestinal epithelium and the peripheral lymphoid tissues and peritoneum. Most γ/δ T cells are CD4-/CD8-, some are CD8+. T cells expressing the TCR γ/δ have been shown to play a role in oral tolerance, tumor-associated tolerance and autoimmune disease. It has been reported that γ/δ T cells also play a principal role in Antigen presentation. Immobilized UC7-13D5 Antibody has been reported to activate TCR-γ/δ-bearing T cells in vitro and to deplete peripheral TCR-γ/δ-bearing T cells in vivo.