Available Sizes: 20 Tests, 50 Tests, 100 Tests.
Background
The Cy34. 1 monoclonal Antibody specifically binds to the B-lymphocyte differentiation Antigen CD22 on strains having the Lyb-8. 2 alloAntigen (e. g., A, BALB/c, CBA, C3H/He, C57BL, C57L, C58, SJL, SWR, but not AKR, DBA/1, DBA/2, NZB, PL). CD22 is expressed at high levels on mature peripheral B lymphocytes (follicular and marginal zone), B-1 cells (CD5+ B cells) and plasma cells. It is a member of the Ig gene superfamily and associates with the B-cell Antigen receptor. Its sialic acid- binding immunoglobulin-like lectin (siglec) extracellular region mediates B-cell adhesion to ligands on endothelial cells in the bone marrow. Its intracellular domain is phosphorylated after cross-linking of Antigen receptor or MHC class II Antigen. It is involved in negative regulation of B-cell activation and protection from autoimmunity. B-cell proliferative responses to LPS or Anti-mouse Ig µ chain are augmented in the presence of Cy34. 1 mAb.
Host
Mouse.
Species Reactivity
Mouse.
Synonyms
B-cell receptor CD22, Cd22, B-lymphocyte cell adhesion molecule, BL-CAM, Sialic acid-binding Ig-like lectin 2, Siglec-2, T-cell surface Antigen Leu-14, CD22, Lyb-8, Siglec2.
Conjugation
PE.
Isotype
N/A.
Applications
FCM.
Concentration
N/A.
Buffer
PBS with 0. 05% Proclin300, 1% BSA.
Storage Conditions
Store at 2~8℃ and protected from prolonged exposure to light. Do not freeze.
Gene-ID
N/A.