PSG Antibodies

PSG (Pregnancy-Specific Glycoprotein) antibodies are designed to target and detect members of the PSG family of proteins. PSGs are a subset of the carcinoembryonic antigen (CEA) family, and they are primarily expressed in the placenta during pregnancy. These glycoproteins play crucial roles in immunoregulation, particularly in protecting the fetus from maternal immune responses, promoting placental development, and ensuring a successful pregnancy. PSGs are involved in modulating immune tolerance, angiogenesis, and cell adhesion processes, all of which are essential for proper fetal development.

Applications of PSG Antibodies

• Western Blotting (WB): PSG antibodies are used to detect PSG proteins in placental tissues and maternal serum. This application helps quantify PSG levels in different pregnancy stages or under pathological conditions such as preeclampsia.
• Enzyme-Linked Immunosorbent Assay (ELISA): PSG antibodies are frequently employed in ELISA to measure the concentration of PSG proteins in biological fluids. This is particularly useful in pregnancy-related diagnostics and research on pregnancy-associated disorders.
• Immunohistochemistry (IHC): PSG antibodies allow for the visualization of PSG expression in placental tissue sections, providing information on the spatial distribution of PSGs in normal and abnormal placental development.
• Immunofluorescence (IF): In IF applications, PSG antibodies are used to stain placental and maternal tissues to investigate the localization of PSGs and their involvement in cellular adhesion and immune modulation.

PSG Antibodies in Disease Research

• Pregnancy Complications: PSGs are critical for normal pregnancy, and disruptions in PSG expression are linked to various complications such as preeclampsia, recurrent miscarriage, and placental dysfunction. PSG antibodies are used to study changes in PSG levels in these conditions and to explore their roles as potential biomarkers for adverse pregnancy outcomes.
• Cancer Research: Some studies have shown that PSGs may be expressed in certain cancers, including breast, ovarian, and gastrointestinal cancers. PSG antibodies help explore the potential oncogenic roles of PSG proteins, particularly in modulating immune escape and tumor angiogenesis.
• Autoimmune Diseases: PSGs have immunomodulatory functions, and their role in promoting immune tolerance is being explored in the context of autoimmune diseases. PSG antibodies are employed to investigate their influence on immune regulation beyond pregnancy, particularly in diseases where immune tolerance mechanisms are impaired.

PSG antibodies are vital tools for exploring the molecular and immunological functions of pregnancy-specific glycoproteins. Their use in research has expanded beyond pregnancy to include potential applications in cancer immunology and autoimmune diseases. By enabling the precise detection and quantification of PSG proteins, PSG antibodies provide critical insights into the role of these glycoproteins in placental development, immune regulation, and disease.