Ubiquitin Antibodies

Ubiquitin antibodies are specialized reagents designed to detect and study ubiquitin, a small regulatory protein that tags other proteins for degradation via the ubiquitin-proteasome system (UPS). Ubiquitination is a crucial cellular process involved in protein turnover, cell cycle regulation, DNA repair, signal transduction, and stress responses. 

Content: Ubiquitin is a 76-amino acid protein that can be covalently attached to lysine residues on target proteins through a process known as ubiquitination. This attachment marks the protein for degradation by the 26S proteasome or can alter its cellular location, activity, or interactions.  Ubiquitin antibodies are designed to target:

  • Mono-Ubiquitin: These antibodies can detect individual ubiquitin molecules, useful for studying processes where single ubiquitin tags play a role, such as endocytosis and receptor trafficking.
  • Poly-Ubiquitin Chains: Ubiquitin can form chains linked via different lysine residues (e.g., K48, K63, K11). Antibodies specific to these linkages allow researchers to differentiate between proteasomal degradation signals (K48-linked chains) and non-degradative signaling pathways (e.g., K63-linked chains involved in DNA repair and immune signaling).

Applications:

  • Cancer Research:
    • Understanding Oncogenesis: Dysregulation of ubiquitination processes is a hallmark of many cancers. Overexpression or mutation of E3 ubiquitin ligases, for instance, can lead to the stabilization of oncoproteins or the degradation of tumor suppressors. Ubiquitin antibodies are used to study these mechanisms, identify therapeutic targets, and assess the efficacy of drugs targeting the UPS.
  • Neurodegenerative Disease Research:
    • Immunohistochemistry (IHC): Ubiquitin antibodies are utilized in IHC to visualize ubiquitinated protein aggregates in brain tissue, helping to characterize disease pathology and progression.
  • Drug Development and Therapeutics:
    • Screening for Ubiquitin Pathway Modulators: Small molecule inhibitors targeting the UPS are being developed for various diseases. Ubiquitin antibodies aid in the screening of compounds that modulate ubiquitination, helping in drug discovery and development efforts.

In summary, ubiquitin antibodies are indispensable tools for studying the ubiquitin-proteasome system and its implications in health and disease.

AffiAB® Anti-ubiquitin Antibody
CAT# AFG-BMG-1602
Size: 100 µl
193.08 193.08 USD
742.85 742.85 USD
AffiAB® Anti-Ubiquitin Monoclonal Antibody
CAT# AFG-BMG-0307
Size: 100 µg
312.68 312.68 USD
AffiAB® Anti-Ubiquitin Rabbit Polyclonal Antibody
CAT# AFG-BMG-0303
Size: 100 µg
312.68 312.68 USD
382.50 382.5 USD
AffiAB®​ Anti-Ubiquitin Antibody
CAT# AFG-QDB-1718
Size: 50 μg
561.20 561.2 USD
AffiAB®​ Anti-Ubiquitin Antibody
CAT# AFG-QDB-1717
Size: 200 μg
869.90 869.9 USD
AffiAB®​ Anti-Ubiquitin Antibody
CAT# AFG-QDB-1716
Size: 200 μg
869.90 869.9 USD
AffiAB®​ Anti-Ubiquitin Antibody
CAT# AFG-QDB-0239
Size: 100 μg
574.85 574.85 USD
AffiAB®​ Anti-Ubiquitin Antibody
CAT# AFG-QDB-0238
Size: 100 μg
563.30 563.3000000000001 USD
625.20 625.2 USD
420.00 420.0 USD
380.40 380.40000000000003 USD
380.40 380.40000000000003 USD
380.40 380.40000000000003 USD
380.40 380.40000000000003 USD
380.40 380.40000000000003 USD
380.40 380.40000000000003 USD
380.40 380.40000000000003 USD
625.20 625.2 USD
420.00 420.0 USD
380.40 380.40000000000003 USD
380.40 380.40000000000003 USD
380.40 380.40000000000003 USD
380.40 380.40000000000003 USD
380.40 380.40000000000003 USD
380.40 380.40000000000003 USD
380.40 380.40000000000003 USD
625.20 625.2 USD
420.00 420.0 USD
380.40 380.40000000000003 USD
380.40 380.40000000000003 USD
380.40 380.40000000000003 USD
380.40 380.40000000000003 USD
380.40 380.40000000000003 USD
380.40 380.40000000000003 USD
380.40 380.40000000000003 USD
AffiAB® Anti-Ubiquitin Antibody (N-term)
CAT# AFG-BRB-22776
Size: 80 μL
552.30 552.3000000000001 USD
663.00 663.0 USD
663.00 663.0 USD
663.00 663.0 USD
663.00 663.0 USD
756.15 756.15 USD
602.25 602.25 USD
688.65 688.65 USD
1,043.70 1043.7 USD
AffiAB® Anti-Ubiquitin VHH Antibody
CAT# AFG-JTD-18
Size: 100 µg
372.60 372.6 USD
458.00 458.0 USD
AffiAB® Human Ubiquitin Antibody
CAT# AFG-SYP-2352
Size: 150 μg
458.00 458.0 USD
AffiAB® Rabbit Anti-Ubiquitin Antibody
CAT# AFG-DDA-8635
Size: 100 μL
284.05 284.05 USD
AffiAB® Rabbit anti-Ubiquitin (pS65) Antibody
CAT# AFG-DDA-2790
Size: 100 μL
284.05 284.05 USD
AffiAB® Rabbit anti-Ubiquitin (pS65) Antibody
CAT# AFG-YBP-8219
Size: 100 µL
457.00 457.0 USD
AffiAB® Anti-Ubiquitin VHH
CAT# AFG-JTB-001
Size: 100 µg
Conjugation: Unconjugated
300.00 300.0 USD
AffiAB® Anti-Ubiquitin D Antibody [JJ084-09]
CAT# AFG-HB-4003
Size: 100 μL
496.50 496.5 USD
AffiAB® Anti-Ubiquitin Antibody [ST46-03]
CAT# AFG-HB-4002
Size: 100 μL
496.50 496.5 USD
AffiAB® Anti-Ubiquitin Antibody
CAT# AFG-HB-4001
Size: 100 μL
433.50 433.5 USD
433.50 433.5 USD
AffiAB® Ubiquitin Antibody- Ready to use
CAT# AFG-NOV-356
Size: 7 mL
574.00 574.0 USD
AffiAB® Ubiquitin Antibody- Concentrate
CAT# AFG-NOV-355
Size: 0.2 mL
562.00 562.0 USD
AffiAB® Ubiquitin (6G6) Mouse Monoclonal Antibody
CAT# AFG-EKA-00194
Size: 100 µL
246.00 246.0 USD