STEAP Antibodies

Function and Importance of STEAP Antibodies: STEAP antibodies are designed to detect specific STEAP proteins in biological samples, enabling researchers to study their expression patterns, interactions, and functional roles in metal ion transport and redox regulation. STEAP proteins are involved in the uptake and metabolism of essential metals, which are crucial for processes such as enzyme activity, mitochondrial function, and cellular respiration. Dysregulation of STEAP expression is linked to several diseases, including cancer and metabolic disorders.

Applications of STEAP antibodies include:

• Western Blot (WB): Used to detect STEAP proteins in cell or tissue lysates, allowing researchers to study their expression under different physiological and pathological conditions.
• Immunohistochemistry (IHC) and Immunofluorescence (IF): Employed to visualize the localization of STEAP proteins in tissues and cells, particularly in cancerous tissues where STEAP1 and STEAP2 are overexpressed.
• Flow Cytometry (FACS): Applied to assess the expression of STEAP proteins on the cell surface, especially in cancer cells or immune cells involved in metal transport.

STEAP Antibody Applications in Research:

• Cancer Research: STEAP1 and STEAP2 antibodies are widely used in cancer research to explore their roles in tumor progression, metastasis, and response to therapy. STEAP1 is a promising target for cancer immunotherapy due to its overexpression in prostate cancer and other tumors.
• Metabolic Disease and Inflammation Research: STEAP4 antibodies are used to study the regulation of inflammation in adipose tissue and its role in metabolic diseases like obesity and type 2 diabetes. These studies aim to identify therapeutic targets for reducing chronic inflammation and improving metabolic health.
• Neurobiology and Oxidative Stress Research: STEAP antibodies may be used to explore the role of metal ion homeostasis in neurodegenerative diseases where oxidative stress and metal dysregulation are contributing factors.

STEAP antibodies are valuable tools for investigating the roles of STEAP proteins in metal ion homeostasis, cancer, inflammation, and metabolic disorders. By targeting specific STEAP proteins, researchers can explore their contributions to cellular metal uptake, redox balance, and disease progression. STEAP antibodies are particularly useful in cancer research, where STEAP1 and STEAP2 serve as potential biomarkers and therapeutic targets.