SERPINC Antibodies

Function and Importance of SERPINC Antibodies: SERPINC antibodies are designed to detect and quantify Antithrombin III in biological samples. This protein is primarily produced in the liver and circulates in the bloodstream, where it binds to and inactivates several coagulation factors, including thrombin, factor IXa, factor Xa, and factor XIa. SERPINC's activity is significantly enhanced by heparin, a glycosaminoglycan that acts as an anticoagulant by accelerating the inhibitory function of SERPINC.

Applications of SERPINC antibodies include:

• Western Blot (WB): Detects SERPINC in lysates from tissues or plasma, allowing researchers to study the expression and regulation of Antithrombin III under different physiological and pathological conditions.
• Enzyme-Linked Immunosorbent Assay (ELISA): Quantifies the concentration of SERPINC in plasma, serum, or other biological fluids, making it useful for diagnostic applications and in studying coagulation disorders.
• Immunohistochemistry (IHC): Enables the localization of SERPINC in tissue sections, revealing patterns of expression in various tissues, particularly in the liver and endothelial cells of blood vessels.
• Flow Cytometry (FACS): Used to analyze the expression of SERPINC on cell surfaces or intracellular compartments, especially in endothelial cells and hepatocytes.

SERPINC Antibody Applications in Research and Diagnostics:

• Coagulation Studies: SERPINC antibodies are used to study coagulation pathways and the regulation of thrombin and factor Xa inhibition. They are also employed in research focused on heparin’s interaction with SERPINC and its clinical implications in anticoagulant therapy.
• Thrombosis and Hemostasis Research: Researchers use SERPINC antibodies to investigate the molecular mechanisms underlying coagulation disorders, including antithrombin deficiency and its effects on thrombus formation.
• Liver Function and Disease Studies: SERPINC antibodies are utilized to study liver function, particularly in relation to the production and secretion of SERPINC. In diseases such as cirrhosis or liver failure, SERPINC levels are often reduced, leading to complications in coagulation balance.

SERPINC antibodies are powerful tools for understanding the physiological role of Antithrombin III in coagulation regulation and its involvement in thrombotic disorders. They enable researchers to investigate SERPINC’s expression, function, and interaction with coagulation factors, providing key insights into the prevention and management of thrombotic diseases.