SCF Antibodies

SCF (Stem Cell Factor) antibodies are designed to detect Stem Cell Factor (SCF), also known as c-Kit Ligand or Mast Cell Growth Factor, a key growth factor involved in the regulation of hematopoiesis, stem cell maintenance, survival, and proliferation of various cell types, particularly in the blood and immune systems. 

Applications of SCF Antibodies

• Western Blotting (WB): SCF antibodies are used in western blotting to detect and quantify SCF expression in cell or tissue lysates. This application helps researchers study SCF levels under different physiological or pathological conditions, such as stem cell differentiation or cancer progression.
• Immunohistochemistry (IHC): SCF antibodies are employed in IHC to localize SCF in tissue sections. This is particularly valuable for studying the role of SCF in hematopoietic organs like the bone marrow, and its involvement in the development of mast cells and melanocytes.
• Immunofluorescence (IF): In immunofluorescence assays, SCF antibodies allow researchers to visualize SCF expression in various cell types, particularly in stem cell niches or tissues where SCF plays a critical regulatory role.

SCF Antibodies in Disease Research

• Cancer: Dysregulation of the SCF/c-Kit signaling pathway is associated with several cancers, including gastrointestinal stromal tumors (GISTs), leukemia, melanoma, and mastocytosis. Overexpression or mutations in c-Kit can lead to uncontrolled cell growth and survival. SCF antibodies are used in cancer research to study the role of SCF in tumor progression, angiogenesis, and resistance to therapies.
• Hematological Disorders: SCF is critical for the regulation of hematopoietic stem cells, and its dysregulation can lead to disorders such as aplastic anemia and myeloproliferative disorders. SCF antibodies are employed in research to investigate how SCF influences blood cell development and how targeting SCF/c-Kit signaling could provide therapeutic benefits in hematological diseases.
• Pigmentation Disorders: SCF’s role in melanocyte development makes it relevant in the study of pigmentation disorders. SCF antibodies are used in research on diseases like vitiligo and albinism, where melanocyte function is impaired.

SCF antibodies are indispensable tools for investigating the role of Stem Cell Factor in regulating stem cell biology, hematopoiesis, and immune cell function. By facilitating the detection and quantification of SCF in various experimental systems, these antibodies provide valuable insights into how SCF influences cellular proliferation, survival, and differentiation in both normal physiology and disease conditions.