RPS17 Antibodies

RPS17 antibodies are designed to detect Ribosomal Protein S17 (RPS17), a component of the 40S subunit of ribosomes, which plays an essential role in protein synthesis. Ribosomes are cellular structures that facilitate the translation of mRNA into proteins, and they are made up of two subunits: the 40S and 60S subunits. RPS17 is one of the structural proteins of the 40S subunit, and like other ribosomal proteins, it is involved in the assembly and function of the ribosome.

Applications of RPS17 Antibodies

• Western Blotting (WB): RPS17 antibodies are commonly used in western blotting to detect and quantify RPS17 expression in cell or tissue lysates. This helps researchers monitor the levels of RPS17 in different experimental conditions, such as during ribosome biogenesis or cellular stress.
• Immunoprecipitation (IP): RPS17 antibodies can be used to immunoprecipitate RPS17, allowing researchers to study its interactions with other ribosomal proteins and RNAs, as well as its involvement in ribosome assembly and function.
• Flow Cytometry (FC): In flow cytometry, RPS17 antibodies can be applied to detect and quantify RPS17 in various cell populations, especially in studies focusing on cell cycle regulation or cellular stress responses.

RPS17 Antibodies in Disease Research

• Ribosomopathies: Mutations in RPS17 have been linked to certain ribosomopathies, such as Diamond-Blackfan anemia (DBA), a rare congenital disorder characterized by impaired red blood cell production. DBA results from mutations in ribosomal proteins, including RPS17, leading to defective ribosome biogenesis.
• Protein Synthesis Regulation: RPS17 is essential for protein synthesis, and disruptions in its function can lead to global changes in translation rates, affecting cellular homeostasis. RPS17 antibodies are used to study how ribosomal proteins contribute to the regulation of protein synthesis under different physiological and pathological conditions, such as stress or disease.
• Cell Cycle and Apoptosis: Ribosomal proteins, including RPS17, have been implicated in extraribosomal functions, such as regulating the cell cycle and apoptosis. RPS17 antibodies help researchers explore how ribosomal proteins influence these processes and contribute to the balance between cell growth and programmed cell death.

RPS17 antibodies are crucial tools for studying the role of RPS17 in ribosome assembly, protein synthesis, and cellular regulation. By facilitating the detection, localization, and analysis of RPS17 in various experimental models, these antibodies provide valuable insights into the function of ribosomal proteins in both normal physiology and disease.