RFTN Antibodies

RFTN (Raftlin) antibodies are designed to detect Raftlin (RFTN1), a lipid raft-associated protein that plays a critical role in immune cell signaling and membrane organization. Raftlin is primarily expressed in B cells and other immune cells and is involved in modulating signal transduction pathways by organizing lipid rafts—microdomains in the plasma membrane that serve as platforms for protein interactions and signaling cascades. 

Applications of RFTN Antibodies

• Immunofluorescence (IF): In immunofluorescence assays, RFTN antibodies allow researchers to visualize Raftlin at the plasma membrane and within lipid rafts, facilitating the study of membrane organization and signaling complex formation in immune cells.
• Immunoprecipitation (IP): RFTN antibodies can be used to immunoprecipitate Raftlin from cell lysates, helping researchers investigate Raftlin’s interactions with other proteins involved in signaling pathways, particularly in B-cell and T-cell receptor signaling.
• Flow Cytometry (FC): In flow cytometry, RFTN antibodies are used to quantify Raftlin expression in various immune cell populations, particularly in studies focused on immune activation, signaling, and membrane organization.

RFTN Antibodies in Disease Research

• Immunological Disorders: Raftlin is critical for proper immune cell signaling, and disruptions in its function can lead to immune system dysregulation. Altered Raftlin expression or function can impair B-cell activation, making RFTN antibodies useful in studying autoimmune diseases or immunodeficiencies where immune signaling is defective.
• Cancer: Since Raftlin is involved in the regulation of immune cell signaling, it may play a role in cancer progression, particularly in cancers of the immune system such as lymphomas or leukemias. RFTN antibodies are used to study how changes in lipid raft organization affect cancer cell signaling and immune evasion.
• Signal Transduction and Membrane Dynamics: Raftlin’s ability to modulate signaling through the organization of lipid rafts makes it a key player in various signal transduction pathways. RFTN antibodies help explore how changes in membrane dynamics affect cellular signaling, particularly in immune cells.

RFTN antibodies are essential tools for studying the role of Raftlin in immune cell signaling, lipid raft organization, and membrane dynamics. By facilitating the detection and analysis of Raftlin expression and function, these antibodies provide critical insights into how lipid rafts contribute to immune system regulation, signal transduction, and disease processes.