PTTG Antibodies

PTTG (Pituitary Tumor Transforming Gene) antibodies are designed to target and detect the PTTG protein, which plays a crucial role in cell cycle regulation, mitosis, and tumorigenesis. PTTG, also known as securin, is a key protein involved in preventing premature sister chromatid separation during mitosis. Its overexpression is associated with tumorigenesis, particularly in pituitary adenomas, but also in various other cancers, such as colorectal, breast, and lung cancer.

Applications of PTTG Antibodies

• Western Blotting (WB): PTTG antibodies are employed to detect PTTG expression in cell and tissue lysates, helping researchers quantify PTTG protein levels in normal and tumor cells. This is particularly important in studies exploring PTTG’s role in cancer progression.
• Immunohistochemistry (IHC): These antibodies are used to visualize PTTG expression in tissue sections, particularly in tumor samples. IHC allows for the study of PTTG’s spatial distribution within tissues, providing insights into how its overexpression correlates with tumorigenesis.
• Immunofluorescence (IF): PTTG antibodies enable the visualization of PTTG within cells, facilitating studies on the cellular localization of PTTG during different phases of the cell cycle and in response to DNA damage.

PTTG Antibodies in Disease Research

• Cancer Research: PTTG is frequently overexpressed in various cancers, including pituitary adenomas, colorectal cancer, and breast cancer. Overexpression of PTTG is associated with poor prognosis, tumor invasiveness, and metastasis. PTTG antibodies are used to investigate how PTTG contributes to oncogenic signaling pathways, its role in tumor progression, and potential therapeutic targets for modulating PTTG activity.
• Cell Cycle and Genomic Instability: Due to PTTG’s role in mitotic regulation, defects in PTTG expression or function can lead to chromosomal instability, a hallmark of many cancers. PTTG antibodies help elucidate how alterations in PTTG levels or activity contribute to improper chromosome segregation and genomic instability in cancer cells.
• Pituitary Tumor Studies: PTTG was originally identified in pituitary tumors, where its overexpression correlates with tumor growth and invasiveness. PTTG antibodies are used to explore its role in pituitary adenomas, providing insights into how its dysregulation contributes to the development and progression of these tumors.

PTTG antibodies are vital research tools for exploring the molecular mechanisms of cell cycle regulation, tumorigenesis, and genomic stability. By enabling specific detection and quantification of PTTG protein in various experimental systems, these antibodies facilitate a deeper understanding of how PTTG contributes to cancer development, tumor progression, and mitotic regulation.