Overview of PSMB Antibodies

PSMB antibodies are a specific type of antibodies that target the proteasome subunit beta (PSMB) proteins. The proteasome is a large protease complex responsible for degrading unneeded or damaged proteins by proteolysis, a chemical reaction that breaks peptide bonds. Within the proteasome, the beta subunits, including PSMB1, PSMB2, PSMB3, PSMB4, PSMB5, PSMB6, PSMB7, and PSMB8, form the core of the proteolytic chamber and are essential for its enzymatic activity.

Content of PSMB Antibodies

Functionality:
  • Proteasome Structure: The 20S proteasome core consists of 28 subunits arranged in four stacked rings. The two outer rings are composed of alpha subunits, and the two inner rings are made up of beta subunits, including PSMB proteins.
  • Enzymatic Activity: PSMB subunits are involved in the catalytic activity of the proteasome, responsible for degrading ubiquitinated proteins into peptides.

Importance in Cellular Processes:
  • Protein Degradation: PSMB subunits play a crucial role in the ubiquitin-proteasome pathway, which regulates protein turnover and maintains cellular homeostasis.
  • Cell Cycle Regulation: The proteasome degrades cyclins and other regulatory proteins, controlling cell cycle progression.
  • Immune Response: PSMB8 (also known as LMP7) is involved in generating peptides for antigen presentation on MHC class I molecules, crucial for immune surveillance.

Clinical Relevance:
  • Disease Associations: Alterations in PSMB subunit expression or function are linked to various diseases, including cancer, neurodegenerative disorders, and autoimmune diseases.
  • Drug Targets: Inhibitors targeting the proteasome, such as bortezomib, are used in cancer therapy, particularly for multiple myeloma. Understanding the role of PSMB subunits can help in designing more specific and effective treatments.

Applications in Research:
  • Biomarker Discovery: PSMB antibodies are used to detect and quantify PSMB proteins in tissues and cell lines, aiding in research on disease mechanisms and potential biomarkers.
  • Functional Studies: By using PSMB antibodies, researchers can investigate the role of specific proteasome subunits in various cellular processes.
  • Therapeutic Development: PSMB antibodies can be utilized in the development and testing of new drugs that target the proteasome, enhancing the efficacy and specificity of treatments.
AffiAB® Rabbit Anti-PSMB2 Antibody
CAT# AFG-DDA-6678
Size: 100 μL
317.30 317.3 USD
AffiAB® Rabbit Anti-PSMB10 Antibody
CAT# AFG-DDA-6675
Size: 100 μL
317.30 317.3 USD
AffiAB® Rabbit Anti-PSMB5 Antibody
CAT# AFG-DDA-6640
Size: 100 μL
317.30 317.3 USD
AffiAB® Rabbit Anti-PSMB9 Antibody
CAT# AFG-DDA-6636
Size: 100 μL
317.30 317.3 USD
AffiAB® Rabbit Anti-PSMB1 Antibody
CAT# AFG-DDA-6614
Size: 100 μL
317.30 317.3 USD
AffiAB® Rabbit Anti-PSMB4 Antibody
CAT# AFG-DDA-5669
Size: 100 μL
308.75 308.75 USD
AffiAB® Rabbit anti-PSMB6 Antibody
CAT# AFG-DDA-3646
Size: 100 μL
284.05 284.05 USD
AffiAB® Rabbit anti-PSMB8 Antibody
CAT# AFG-DDA-3106
Size: 100 μL
284.05 284.05 USD
AffiAB® PSMB9 Polyclonal Antibody
CAT# AFG-PAB-12242
Size: 150 µL
Conjugation: Unconjugated
785.00 785.0 USD
AffiAB® PSMB8 Polyclonal Antibody
CAT# AFG-PAB-12241
Size: 150 µL
Conjugation: Unconjugated
785.00 785.0 USD
AffiAB® PSMB7 Polyclonal Antibody
CAT# AFG-PAB-12240
Size: 150 µL
Conjugation: Unconjugated
785.00 785.0 USD
AffiAB® PSMB6 Polyclonal Antibody
CAT# AFG-PAB-12239
Size: 150 µL
Conjugation: Unconjugated
785.00 785.0 USD
AffiAB® PSMB5 Polyclonal Antibody
CAT# AFG-PAB-12238
Size: 150 µL
Conjugation: Unconjugated
785.00 785.0 USD
AffiAB® PSMB4 Polyclonal Antibody
CAT# AFG-PAB-12237
Size: 150 µL
Conjugation: Unconjugated
785.00 785.0 USD
AffiAB® PSMB3 Polyclonal Antibody
CAT# AFG-PAB-12236
Size: 150 µL
Conjugation: Unconjugated
785.00 785.0 USD
AffiAB® PSMB2 Polyclonal Antibody
CAT# AFG-PAB-12235
Size: 150 µL
Conjugation: Unconjugated
785.00 785.0 USD
AffiAB® PSMB11 Polyclonal Antibody
CAT# AFG-PAB-12234
Size: 150 µL
Conjugation: Unconjugated
785.00 785.0 USD
AffiAB® PSMB10 Polyclonal Antibody
CAT# AFG-PAB-12233
Size: 150 µL
Conjugation: Unconjugated
785.00 785.0 USD
AffiAB® PSMB1 Polyclonal Antibody
CAT# AFG-PAB-12232
Size: 150 µL
Conjugation: Unconjugated
785.00 785.0 USD
AffiAB® Rabbit anti-PSMB9 Antibody
CAT# AFG-YBP-6677
Size: 100 µL
457.00 457.0 USD
AffiAB® Rabbit anti-PSMB8 Antibody
CAT# AFG-YBP-6676
Size: 100 µL
457.00 457.0 USD
AffiAB® Rabbit anti-PSMB6 Antibody
CAT# AFG-YBP-6675
Size: 100 µL
457.00 457.0 USD
AffiAB® Rabbit anti-PSMB5 Antibody
CAT# AFG-YBP-6674
Size: 100 µL
457.00 457.0 USD
AffiAB® Rabbit anti-PSMB4 Antibody
CAT# AFG-YBP-6673
Size: 100 µL
457.00 457.0 USD
AffiAB® Rabbit anti-PSMB2 Antibody
CAT# AFG-YBP-6672
Size: 100 µL
457.00 457.0 USD
AffiAB® Rabbit anti-PSMB10 Antibody
CAT# AFG-YBP-6671
Size: 100 µL
457.00 457.0 USD
AffiAB® Rabbit anti-PSMB1 Antibody
CAT# AFG-YBP-6670
Size: 100 µL
457.00 457.0 USD
AffiAB® Anti-PSMB7 Antibody
CAT# AFG-HB-3287
Size: 100 μL
283.50 283.5 USD
AffiAB® Anti-PSMB3 Antibody
CAT# AFG-HB-3286
Size: 100 μL
283.50 283.5 USD
AffiAB® Anti-PSMB2 Antibody
CAT# AFG-HB-3285
Size: 100 μL
283.50 283.5 USD
AffiAB® Anti-PSMB10 Antibody
CAT# AFG-HB-3284
Size: 100 μL
283.50 283.5 USD
AffiAB® Anti-PSMB8
CAT# AFG-IVA-01838
Size: 100 µL
Terminal: N/A
369.55 369.55 USD