NUDT Antibodies

NUDT (Nudix Hydrolase) proteins are a family of enzymes that catalyze the hydrolysis of nucleoside diphosphates linked to other moieties (X), such as nucleotides, nucleotide sugars, and coenzymes. This enzymatic activity plays a crucial role in maintaining the integrity of cellular nucleotide pools by eliminating damaged or oxidized nucleotides, which can otherwise be incorporated into DNA or RNA and cause mutations.

Applications of NUDT Antibodies

NUDT antibodies are indispensable in several experimental contexts, especially in the study of nucleotide metabolism, oxidative stress, and cancer research:

  • Western Blotting: NUDT antibodies are commonly used to detect specific NUDT family members, such as NUDT1 or NUDT15, in cell or tissue lysates. This helps researchers assess changes in NUDT protein levels in response to oxidative stress, DNA damage, or chemotherapy treatment.
  • Immunohistochemistry (IHC): NUDT antibodies can be applied to tissue sections to visualize the distribution and expression of NUDT proteins in various tissues. This is particularly useful for studying the role of NUDT proteins in oxidative damage repair within different organs, such as the brain, liver, or cancer tissues.
  • Immunocytochemistry (ICC): In cultured cells, NUDT antibodies are used to study the subcellular localization of NUDT proteins, which are often localized to the cytoplasm, nucleus, or mitochondria. This application helps researchers understand how NUDT proteins respond to cellular stress and prevent the incorporation of oxidized nucleotides into nucleic acids.
Key Characteristics of NUDT Antibodies
  • Isoform-Specificity: NUDT antibodies are designed to be specific to particular NUDT family members, such as NUDT1 or NUDT15, ensuring accurate detection of these proteins in complex biological samples. This specificity is crucial for distinguishing between different NUDT isoforms, which have distinct functions and roles in cellular processes.
  • Cross-reactivity: Many NUDT antibodies exhibit cross-reactivity with homologous proteins across species, including humans, mice, and rats, enabling their use in a wide range of model organisms for biomedical research.
  • Post-translational Modification Sensitivity: Some NUDT antibodies are engineered to detect specific post-translational modifications, such as phosphorylation, on NUDT proteins. This is particularly useful for studying how NUDT activity is regulated in response to cellular signaling or stress.

NUDT antibodies are critical tools in the study of nucleotide metabolism, oxidative stress responses, DNA damage repair, and chemotherapy drug metabolism. Their application in cancer, pharmacogenomics, and oxidative stress-related diseases provides valuable insights into the molecular mechanisms underlying disease progression and therapeutic responses.

AffiAB® Rabbit Anti-NUDT6 Antibody
CAT# AFG-DDA-6855
Size: 100 μL
317.30 317.3 USD
AffiAB® Rabbit Anti-NUDT2 Antibody
CAT# AFG-DDA-5736
Size: 100 μL
308.75 308.75 USD
AffiAB® Rabbit anti-NUDT21 Antibody
CAT# AFG-DDA-1543
Size: 100 μL
274.55 274.55 USD
AffiAB® Rabbit anti-NUDT15 Antibody
CAT# AFG-DDA-0761
Size: 100 μL
256.50 256.5 USD
AffiAB® NUDT9 Polyclonal Antibody
CAT# AFG-PAB-10493
Size: 150 µL
Conjugation: Unconjugated
1,112.50 1112.5 USD
AffiAB® NUDT8 Polyclonal Antibody
CAT# AFG-PAB-10492
Size: 150 µL
Conjugation: Unconjugated
1,112.50 1112.5 USD
AffiAB® NUDT6 Polyclonal Antibody
CAT# AFG-PAB-10491
Size: 150 µL
Conjugation: Unconjugated
1,112.50 1112.5 USD
AffiAB® NUDT5 Polyclonal Antibody
CAT# AFG-PAB-10490
Size: 100 µg
Conjugation: Unconjugated
533.50 533.5 USD
AffiAB® NUDT21 Polyclonal Antibody
CAT# AFG-PAB-10489
Size: 150 µL
Conjugation: Unconjugated
1,112.50 1112.5 USD
AffiAB® NUDT2 Polyclonal Antibody
CAT# AFG-PAB-10488
Size: 100 µL
Conjugation: Unconjugated
335.50 335.5 USD
AffiAB® NUDT19 Polyclonal Antibody
CAT# AFG-PAB-10487
Size: 150 µL
Conjugation: Unconjugated
1,112.50 1112.5 USD
AffiAB® NUDT16 Polyclonal Antibody
CAT# AFG-PAB-10486
Size: 150 µL
Conjugation: Unconjugated
1,112.50 1112.5 USD
AffiAB® NUDT15 Polyclonal Antibody
CAT# AFG-PAB-10485
Size: 100 µg
Conjugation: Unconjugated
533.50 533.5 USD
AffiAB® NUDT14 Polyclonal Antibody
CAT# AFG-PAB-10484
Size: 100 µg
Conjugation: Unconjugated
533.50 533.5 USD
AffiAB® NUDT13 Polyclonal Antibody
CAT# AFG-PAB-10483
Size: 100 µg
Conjugation: Unconjugated
533.50 533.5 USD
AffiAB® NUDT12 Polyclonal Antibody
CAT# AFG-PAB-10482
Size: 150 µL
Conjugation: Unconjugated
1,112.50 1112.5 USD
AffiAB® NUDT11 Polyclonal Antibody
CAT# AFG-PAB-10481
Size: 100 µg
Conjugation: Unconjugated
533.50 533.5 USD
AffiAB® NUDT1 Polyclonal Antibody
CAT# AFG-PAB-10480
Size: 150 µL
Conjugation: Unconjugated
1,112.50 1112.5 USD
AffiAB® Rabbit anti-NUDT6 Antibody
CAT# AFG-YBP-5871
Size: 100 µL
457.00 457.0 USD
AffiAB® Rabbit anti-NUDT21 Antibody
CAT# AFG-YBP-5870
Size: 100 µL
457.00 457.0 USD
AffiAB® Rabbit anti-NUDT2 Antibody
CAT# AFG-YBP-5869
Size: 100 µL
457.00 457.0 USD
AffiAB® Rabbit anti-NUDT15 Antibody
CAT# AFG-YBP-5868
Size: 100 µL
457.00 457.0 USD
AffiAB® Anti-NUDT5 Antibody [JE56-41]
CAT# AFG-HB-2767
Size: 100 μL
496.50 496.5 USD
AffiAB® Anti-NUDT19 Antibody [JE64-49]
CAT# AFG-HB-2766
Size: 100 μL
496.50 496.5 USD