MARC Antibodies

MARC Antibodies are designed to detect and bind to Mitochondrial Amidoxime Reducing Components (MARC), a group of enzymes involved in the detoxification of N-hydroxylated compounds. MARC enzymes are molybdenum-containing proteins that play a crucial role in drug metabolism, particularly in reducing N-hydroxy compounds such as amidoximes and guanidoximes to their corresponding amines, making them an important part of the body's defense system against toxic substances.

Content of MARC Antibody

MARC Antibodies are produced by immunizing animals such as rabbits or mice with peptides or recombinant protein fragments of MARC1 or MARC2. These antibodies can be:

• Polyclonal antibodies: Recognize multiple epitopes on MARC proteins, providing broad detection in various experimental assays.
• Monoclonal antibodies: Bind to a single, specific epitope on the MARC protein, ensuring high specificity and consistency for experimental results.

Application of MARC Antibody

MARC Antibodies are widely used in mitochondrial biology, pharmacology, toxicology, and metabolism research to study the function of MARC1 and MARC2 in the detoxification process and cellular metabolism. Common applications include:

• Mitochondrial Function Studies: MARC Antibodies are widely used in studies focused on mitochondrial function and bioenergetics. Since MARC1 and MARC2 are localized to the outer mitochondrial membrane, they play a role in modulating mitochondrial activity in response to toxic substances. MARC Antibodies help researchers study how these enzymes contribute to mitochondrial defense mechanisms and their role in the broader context of cellular metabolism.
• Pharmacology and Drug Metabolism: MARC enzymes are important in the biotransformation of prodrugs, such as amidoxime-containing prodrugs. MARC Antibodies are used in pharmacological studies to investigate how MARC enzymes metabolize these prodrugs into active forms, as well as their role in drug efficacy and toxicity. By using MARC Antibodies, researchers can evaluate how the activity of MARC1 and MARC2 influences the pharmacokinetics of specific drugs.
• Toxicology Research: MARC Antibodies are also applied in toxicology studies to assess how these enzymes contribute to the detoxification of harmful N-hydroxy compounds. Researchers use MARC Antibodies to evaluate the role of MARC1 and MARC2 in mitigating the toxic effects of xenobiotics and environmental toxins. This research is crucial for understanding how these enzymes protect cells from oxidative damage and chemical-induced apoptosis.

MARC Antibodies are essential tools in mitochondrial biology, pharmacology, and toxicology research. They enable the study of MARC1 and MARC2, which are crucial enzymes in the detoxification of harmful compounds and the metabolism of drugs.