KIAA Antibodies

KIAA Antibodies are designed to target and bind to proteins encoded by KIAA genes. The KIAA family of genes refers to a group of genes that were initially discovered through large-scale sequencing projects aimed at identifying novel human genes. Many KIAA proteins remain poorly characterized, though several are implicated in various cellular functions such as signal transduction, cytoskeletal organization, and regulation of gene expression. Some KIAA proteins are also associated with diseases such as cancer, neurodegenerative disorders, and developmental abnormalities.

Content of KIAA Antibody

KIAA Antibodies are generated by immunizing animals with peptides or protein fragments from KIAA proteins. These antibodies can be monoclonal or polyclonal:

• Polyclonal antibodies: Recognize multiple epitopes on the target KIAA protein, providing broader detection and higher sensitivity.
• Monoclonal antibodies: Bind to a single, specific epitope, ensuring high specificity and consistent performance across different applications.

Application of KIAA Antibody

KIAA Antibodies are extensively used in cellular and molecular biology, especially in studying the unknown or newly discovered KIAA proteins. Common applications include:

• ELISA (Enzyme-Linked Immunosorbent Assay): KIAA Antibodies can be used in ELISA assays to measure the levels of KIAA proteins in biological fluids such as blood, serum, or cell culture supernatants. This application is useful in high-throughput screening for disease biomarkers, where altered expression of specific KIAA proteins may indicate the presence of diseases like cancer or neurodegeneration.
• Cancer Research: Several KIAA proteins are implicated in cancer progression, including metastasis, proliferation, and apoptosis. KIAA Antibodies are used to investigate the expression and function of these proteins in tumor models, contributing to the identification of novel cancer biomarkers or therapeutic targets. For example, KIAA1524 (CIP2A) is known to be overexpressed in several cancers, and its study using KIAA Antibodies has advanced our understanding of its role in oncogenesis.
• Neuroscience Research: KIAA Antibodies are also used to study the role of KIAA proteins in the brain and nervous system. Some KIAA proteins are linked to neurodevelopmental disorders or neurodegenerative diseases such as Alzheimer's and Parkinson's diseases. By using KIAA Antibodies in neuronal cell cultures or brain tissue samples, researchers can explore the involvement of these proteins in neural signaling, synaptic plasticity, and disease mechanisms.

KIAA Antibodies are critical tools for investigating the structure, function, and regulation of KIAA proteins in both normal and pathological conditions. From basic research in cellular processes to the discovery of novel biomarkers in diseases such as cancer and neurodegeneration, these antibodies enable researchers to detect, quantify, and study KIAA proteins.