INSL Antibodies

Insulin-like (INSL) peptides are a family of proteins that play important roles in various physiological processes, including reproduction, development, and metabolism. The INSL family includes several members, such as INSL3, INSL4, INSL5, and INSL6, which share structural similarities with insulin and relaxin proteins. 

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INSL antibodies are highly specific immunological reagents designed to target individual members of the INSL family. These antibodies are available in both monoclonal and polyclonal forms, offering a range of specificity and sensitivity for various applications. Monoclonal antibodies, which recognize a single epitope on the target INSL protein, provide high precision in experimental assays. 

Applications of INSL Antibody

• Reproductive Biology: INSL peptides, particularly INSL3, are essential regulators of reproductive function. INSL3 is crucial for testicular descent during fetal development and plays a role in maintaining male reproductive health in adults. INSL antibodies are commonly used in reproductive biology research to study the expression of INSL3 in the testes and other reproductive tissues. By using techniques like immunohistochemistry (IHC) and Western blotting, researchers can analyze INSL3 expression levels and its involvement in conditions like cryptorchidism (failure of testicular descent) or infertility.
  • INSL3: INSL3 is expressed in Leydig cells of the testes and is involved in male reproductive development. Antibodies against INSL3 are used to study its role in reproductive disorders and its potential as a biomarker for male fertility.
  • INSL5 and INSL6: These members of the INSL family are also involved in reproductive physiology, with INSL5 being associated with gastrointestinal regulation and INSL6 playing roles in spermatogenesis. Antibodies targeting INSL5 and INSL6 can be used to explore their functions in reproduction and metabolism.
• Endocrine and Metabolic Research: INSL peptides, particularly INSL5, are expressed in the gut and are involved in regulating metabolism and energy homeostasis. INSL antibodies are used to investigate the role of these peptides in metabolic disorders, such as obesity and diabetes. Researchers employ INSL antibodies in ELISA and Western blot assays to measure INSL expression in tissues like the pancreas, gastrointestinal tract, and fat, and to study their interactions with metabolic pathways.
  • INSL5: INSL5 is secreted by L-cells in the colon and is implicated in glucose homeostasis and appetite regulation. Researchers use INSL5 antibodies to study its role in metabolic diseases, including diabetes and obesity, by examining its expression levels in tissues and its interaction with metabolic hormones like insulin.

INSL antibodies are essential tools for studying the roles of insulin-like peptides in reproduction, metabolism, and cancer. They enable researchers to detect, quantify, and visualize INSL proteins in various biological systems, helping to elucidate their functions in health and disease. Whether used in Western blotting, immunohistochemistry.