IL20 Antibodies

Interleukin-20 (IL-20) is a cytokine that belongs to the IL-10 family and plays a crucial role in inflammatory processes, tissue homeostasis, and skin health. IL-20 signals through two distinct receptor complexes, IL-20R1/IL-20R2 and IL-22R1/IL-20R2, and is primarily expressed by keratinocytes, monocytes, and certain epithelial cells. 

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IL-20 antibodies are highly specific immunological reagents that bind to IL-20 cytokines or their associated receptors, allowing for the detection, quantification, and functional analysis of IL-20 in biological systems. These antibodies can be monoclonal or polyclonal, depending on the specificity and application required. 

Applications of IL-20 Antibodies
  • Inflammatory Disease Research: IL-20 is heavily implicated in inflammatory skin conditions such as psoriasis. IL-20 antibodies are used in research to investigate how this cytokine drives inflammation and keratinocyte hyperproliferation in psoriatic skin. By using IL-20 antibodies in immunohistochemistry or ELISA assays, researchers can quantify IL-20 levels in patient samples, correlating the cytokine’s expression with disease severity. These antibodies are also critical for studying the therapeutic potential of IL-20 blockade in treating chronic inflammatory diseases like rheumatoid arthritis.
  • Autoimmune Disease Studies: IL-20 has been associated with autoimmune diseases beyond psoriasis, including rheumatoid arthritis (RA) and inflammatory bowel disease (IBD). Researchers utilize IL-20 antibodies to study the role of IL-20 in autoimmunity by examining its expression in diseased tissues and serum. In experimental autoimmune models, IL-20 antibodies help assess the impact of IL-20 inhibition on disease progression. The data derived from these studies provide insights into potential IL-20-based therapies for autoimmune disorders.
  • Wound Healing and Tissue Repair: IL-20 has been implicated in wound healing processes, particularly in epithelial tissues such as the skin and lung. IL-20 antibodies can be used to explore the cytokine's role in epithelial cell proliferation, migration, and tissue repair. In vitro assays using IL-20 neutralizing antibodies can block IL-20 activity, providing insights into its contribution to wound healing. In addition, IL-20 antibodies can help determine if excessive IL-20 expression contributes to pathological wound healing, such as fibrosis or scarring.

IL-20 antibodies are indispensable tools in research areas involving inflammation, autoimmune disease, fibrosis, cancer, and tissue repair. Their ability to detect and quantify IL-20 in biological samples allows researchers to gain critical insights into the biological roles of IL-20 in both normal physiology and disease. These antibodies are also key in exploring the therapeutic potential of targeting IL-20 and its receptors in various inflammatory and autoimmune diseases.

AffiAB® IL20RB Polyclonal Antibody
CAT# AFG-PAB-07433
Size: 100 µg
Conjugation: Unconjugated
335.50 335.5 USD
AffiAB® IL20RA Polyclonal Antibody
CAT# AFG-PAB-07432
Size: 100 µg
Conjugation: Unconjugated
335.50 335.5 USD
AffiAB® IL20 Polyclonal Antibody
CAT# AFG-PAB-07431
Size: 100 µg
Conjugation: Unconjugated
335.50 335.5 USD